Translational research for tuberculosis elimination : priorities, challenges, and actions
Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
Summary Points:
• The WHO End TB Strategy, endorsed by the World Health Assembly in May 2014,
has the ambitious goal of ending the global tuberculosis (TB) epidemic by 2035, with
targets of a 95% decline in deaths due to TB (compared with 2015) and a 90% reduction
in incidence of TB to ten cases/100,000 or less and no TB-affected household
experiencing catastrophic costs due to TB.
• Achieving this goal will only be possible through the development and rapid uptake of
new tools, including rapid point-of-care diagnostics, safe and shorter treatment of
latent TB infection and disease, and an efficacious TB vaccine, combined with efficient
health systems and care provision, and actions on the social determinants of TB.
• Research for TB elimination requires an intensification of efforts across a continuum
from fundamental research to clinical, epidemiological, implementation, health system,
and social science research.
• Enhancing research along the full spectrum, from basic to implementation, and
strengthening research capacity, particularly in low- and middle-income countries
severely affected by the TB epidemics, is crucial for TB elimination.
• The creation of a research-enabling environment that fosters and rewards high-quality
research requires a broad-based, concerted effort by national governments and international
donors to develop and promote TB research and research capacity at the
country level and the effective engagement of all stakeholders.
Description
CITATION: Lienhardt, C., et al. 2016.Translational research for tuberculosis elimination : priorities, challenges, and actions. PLoS Medicine, 13(3): e1001965, doi:10.1371/journal.pmed.1001965.
The original publication is available at http://journals.plos.org/plosmedicine
The original publication is available at http://journals.plos.org/plosmedicine
Keywords
Tuberculosis -- Prevention, Tuberculosis -- Research, World Health Organization
Citation
Lienhardt, C., et al. 2016.Translational research for tuberculosis elimination : priorities, challenges, and actions. PLoS Medicine, 13(3): e1001965, doi:10.1371/journal.pmed.1001965