Translational research for tuberculosis elimination : priorities, challenges, and actions

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dc.contributor.authorLienhardt, Christianen_ZA
dc.contributor.authorLonnroth, Knuten_ZA
dc.contributor.authorMenzies, Dicken_ZA
dc.contributor.authorBalasegaram, Manicaen_ZA
dc.contributor.authorChakaya, Jeremiahen_ZA
dc.contributor.authorCobelens, Franken_ZA
dc.contributor.authorCohn, Jenniferen_ZA
dc.contributor.authorDenkinger, Claudia M.en_ZA
dc.contributor.authorEvans, Thomas G.en_ZA
dc.contributor.authorKallenius, Gunillaen_ZA
dc.contributor.authorKaplan, Gillaen_ZA
dc.contributor.authorKumar, Ajay M. V.en_ZA
dc.contributor.authorMatthiessen, Lineen_ZA
dc.contributor.authorMgone, Charles S.en_ZA
dc.contributor.authorMizrahi, Valerieen_ZA
dc.contributor.authorMukadi, Ya-diulen_ZA
dc.contributor.authorNguyen, Viet Nhungen_ZA
dc.contributor.authorNordstrom, Andersen_ZA
dc.contributor.authorSizemore, Christine F.en_ZA
dc.contributor.authorSpigelman, Melvinen_ZA
dc.contributor.authorSquire, S. Bertelen_ZA
dc.contributor.authorSwaminathan, Soumyaen_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorZumla, Alimuddinen_ZA
dc.contributor.authorWeyer, Karinen_ZA
dc.contributor.authorWeil, Dianaen_ZA
dc.contributor.authorRaviglione, Marioen_ZA
dc.date.accessioned2017-09-15T10:12:18Z
dc.date.available2017-09-15T10:12:18Z
dc.date.issued2016
dc.descriptionCITATION: Lienhardt, C., et al. 2016.Translational research for tuberculosis elimination : priorities, challenges, and actions. PLoS Medicine, 13(3): e1001965, doi:10.1371/journal.pmed.1001965.
dc.descriptionThe original publication is available at http://journals.plos.org/plosmedicine
dc.description.abstractSummary Points: • The WHO End TB Strategy, endorsed by the World Health Assembly in May 2014, has the ambitious goal of ending the global tuberculosis (TB) epidemic by 2035, with targets of a 95% decline in deaths due to TB (compared with 2015) and a 90% reduction in incidence of TB to ten cases/100,000 or less and no TB-affected household experiencing catastrophic costs due to TB. • Achieving this goal will only be possible through the development and rapid uptake of new tools, including rapid point-of-care diagnostics, safe and shorter treatment of latent TB infection and disease, and an efficacious TB vaccine, combined with efficient health systems and care provision, and actions on the social determinants of TB. • Research for TB elimination requires an intensification of efforts across a continuum from fundamental research to clinical, epidemiological, implementation, health system, and social science research. • Enhancing research along the full spectrum, from basic to implementation, and strengthening research capacity, particularly in low- and middle-income countries severely affected by the TB epidemics, is crucial for TB elimination. • The creation of a research-enabling environment that fosters and rewards high-quality research requires a broad-based, concerted effort by national governments and international donors to develop and promote TB research and research capacity at the country level and the effective engagement of all stakeholders.en_ZA
dc.description.urihttp://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1001965
dc.description.versionPublisher's version
dc.format.extent11 pages
dc.identifier.citationLienhardt, C., et al. 2016.Translational research for tuberculosis elimination : priorities, challenges, and actions. PLoS Medicine, 13(3): e1001965, doi:10.1371/journal.pmed.1001965
dc.identifier.issn1549-1676 (online)
dc.identifier.issn1549-1277 (print)
dc.identifier.otherdoi:10.1371/journal.pmed.1001965
dc.identifier.urihttp://hdl.handle.net/10019.1/102240
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Science
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosis -- Preventionen_ZA
dc.subjectTuberculosis -- Researchen_ZA
dc.subjectWorld Health Organizationen_ZA
dc.titleTranslational research for tuberculosis elimination : priorities, challenges, and actionsen_ZA
dc.typeArticleen_ZA
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