High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease
Date
2010
Journal Title
Journal ISSN
Volume Title
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Abstract
Human antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor necrosis factor α and interferon γ (IFN-γ), and the frequency of antigen-specific IFN-γ+CD4+ and IFN- γ+CD8+ cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Description
Keywords
antimycobacterial agent, gamma interferon, tumor necrosis factor alpha, article, bacterial immunity, endemic disease, heritability, human, major clinical study, Mycobacterium, priority journal, quantitative analysis, regulator gene, tuberculosis, Adolescent, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cells, Cultured, Child, Endemic Diseases, Female, Genotype, Humans, Immunity, Innate, Interferon-gamma, Male, Mycobacterium tuberculosis, Phenotype, Principal Component Analysis, South Africa, Tuberculosis, Tumor Necrosis Factor-alpha, Young Adult
Citation
Journal of Infectious Diseases
201
1
201
1