Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?

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dc.contributor.authorPowrie, Y. S. L.en_ZA
dc.contributor.authorSmith, C.en_ZA
dc.date.accessioned2018-10-22T05:48:44Z
dc.date.available2018-10-22T05:48:44Z
dc.date.issued2018-10-16
dc.date.updated2018-10-21T03:19:14Z
dc.descriptionCITATION: Powrie, Y. S. L. & Smith, C. 2018. Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?. Journal of Neuroinflammation, 15:289, d10.1186/s12974-018-1324-0.en_ZA
dc.descriptionThe original publication is available at https://jneuroinflammation.biomedcentral.comen_ZA
dc.description.abstractIt is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration, which is characterised by gradual cognitive decline. Although DHEA is also associated with inflammation in the periphery, the link between DHEA and neuroinflammation in this context is less clear. This review drew from different bodies of literature to provide a more comprehensive picture of peripheral vs central endocrine shifts with advanced age—specifically in terms of DHEA. From this, we have formulated the hypothesis that DHEA decline is also linked to neuroinflammation and that increased localised availability of DHEA may have both therapeutic and preventative benefit to limit neurodegeneration. We provide a comprehensive discussion of literature on the potential for extragonadal DHEA synthesis by neuroglial cells and reflect on the feasibility of therapeutic manipulation of localised, central DHEA synthesis.en_ZA
dc.description.urihttps://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-018-1324-0
dc.description.versionPublisher's versionen_ZA
dc.format.extent21 pagesen_ZA
dc.identifier.citationCITATION: Powrie, Y. S. L. & Smith, C. 2018. Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?. Journal of Neuroinflammation, 15:289, d10.1186/s12974-018-1324-0.en_ZA
dc.identifier.issn1742-2094 (online)
dc.identifier.otherdoi:10.1186/s12974-018-1324-0
dc.identifier.urihttp://hdl.handle.net/10019.1/104582
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCentral intracrine DHEA synthesisen_ZA
dc.subjectSteroidogenesisen_ZA
dc.subjectNeuroinflammationen_ZA
dc.subjectTherapeutic potentialen_ZA
dc.titleCentral intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?en_ZA
dc.typeArticleen_ZA
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