Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?
Date
2018-10-16
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
BMC (part of Springer Nature)
Abstract
It is a well-known fact that DHEA declines on ageing and that it is linked to ageing-related neurodegeneration,
which is characterised by gradual cognitive decline. Although DHEA is also associated with inflammation in the
periphery, the link between DHEA and neuroinflammation in this context is less clear. This review drew from
different bodies of literature to provide a more comprehensive picture of peripheral vs central endocrine shifts with
advanced age—specifically in terms of DHEA. From this, we have formulated the hypothesis that DHEA decline is
also linked to neuroinflammation and that increased localised availability of DHEA may have both therapeutic and
preventative benefit to limit neurodegeneration. We provide a comprehensive discussion of literature on the
potential for extragonadal DHEA synthesis by neuroglial cells and reflect on the feasibility of therapeutic
manipulation of localised, central DHEA synthesis.
Description
CITATION: Powrie, Y. S. L. & Smith, C. 2018. Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?. Journal of Neuroinflammation, 15:289, d10.1186/s12974-018-1324-0.
The original publication is available at https://jneuroinflammation.biomedcentral.com
The original publication is available at https://jneuroinflammation.biomedcentral.com
Keywords
Central intracrine DHEA synthesis, Steroidogenesis, Neuroinflammation, Therapeutic potential
Citation
CITATION: Powrie, Y. S. L. & Smith, C. 2018. Central intracrine DHEA synthesis in ageing-related neuroinflammation and neurodegeneration : therapeutic potential?. Journal of Neuroinflammation, 15:289, d10.1186/s12974-018-1324-0.