Review of diagnostic tests for detection of mycobacterium bovis infection in South African wildlife
Date
2021-01
Journal Title
Journal ISSN
Volume Title
Publisher
Frontiers Media S.A
Abstract
Wildlife tuberculosis is a major economic and conservation concern globally. Bovine
tuberculosis (bTB), caused byMycobacteriumbovis (M. bovis), is themost common form
of wildlife tuberculosis. In South Africa, to date, M. bovis infection has been detected in
24 mammalian wildlife species. The identification of M. bovis infection in wildlife species
is essential to limit the spread and to control the disease in these populations, sympatric
wildlife species and neighboring livestock. The detection of M. bovis-infected individuals
is challenging as only severely diseased animals show clinical disease manifestations and
diagnostic tools to identify infection are limited. The emergence of novel reagents and
technologies to identify M. bovis infection in wildlife species are instrumental in improving
the diagnosis and control of bTB. This review provides an update on the diagnostic tools
to detect M. bovis infection in South African wildlife but may be a useful guide for other
wildlife species.
Description
CITATION: Bernitz N, Kerr TJ, Goosen WJ, Chileshe J, Higgitt RL, Roos EO, Meiring C, Gumbo R, de Waal C, Clarke C, Smith K, Goldswain S, Sylvester TT, Kleynhans L, Dippenaar A, Buss PE, Cooper DV, Lyashchenko KP, Warren RM, van Helden PD, Parsons SDC and Miller MA (2021) Review of Diagnostic
Tests for Detection of Mycobacterium bovis Infection in South African Wildlife. Front. Vet. Sci. 8:588697.
doi.10.3389/fvets.2021.588697
The original publication is available at: frontiersin.org
The original publication is available at: frontiersin.org
Keywords
Mycobacterium bovis, Bovine tuberculosis -- Diagnostics, Tuberculosis in animals, Animals -- South Africa, Immunologic diseases in animals, Animals -- Cytogenetics, Gene expression assays
Citation
Bernitz N, Kerr TJ, Goosen WJ, Chileshe J, Higgitt RL, Roos EO, Meiring C, Gumbo R, de Waal C, Clarke C, Smith K, Goldswain S, Sylvester TT, Kleynhans L, Dippenaar A, Buss PE, Cooper DV, Lyashchenko KP, Warren RM, van Helden PD, Parsons SDC and Miller MA (2021) Review of Diagnostic
Tests for Detection of Mycobacterium bovis Infection in South African Wildlife. Front. Vet. Sci. 8:588697.
doi.10.3389/fvets.2021.588697