Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review

Simple item page
dc.contributor.authorSchiffer, Linaen_ZA
dc.contributor.authorBarnard, Liseen_ZA
dc.contributor.authorBaranowski, Elizabeth S.en_ZA
dc.contributor.authorGilligan, Lorna C.en_ZA
dc.contributor.authorTaylor, Angela E.en_ZA
dc.contributor.authorArlt, Wiebkeen_ZA
dc.contributor.authorShackleton, Cedric H. L.en_ZA
dc.contributor.authorStorbeck, Karl-Heinzen_ZA
dc.date.accessioned2021-07-08T11:18:58Z
dc.date.available2021-07-08T11:18:58Z
dc.date.issued2019-07-27
dc.descriptionCITATION: Schiffer, L. et al. 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review. Journal of Steroid Biochemistry and Molecular Biology, 194:105439, doi:10.1016/j.jsbmb.2019.105439.
dc.descriptionThe original publication is available at https://www.sciencedirect.com
dc.description.abstractAdvances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the serum and urine steroid metabolomes. The quantification of steroid panels is therefore gaining favor over quantification of single marker metabolites in the clinical and research laboratories. However, although the biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still exists between this knowledge and its application to the measured steroid profiles. In this review, we present an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview of the methodology used in steroid profiling is also provided.en_ZA
dc.description.versionPublisher's version
dc.format.extent25 pages : illustrationsen_ZA
dc.identifier.citationSchiffer, L. et al. 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review. Journal of Steroid Biochemistry and Molecular Biology, 194:105439, doi:10.1016/j.jsbmb.2019.105439.
dc.identifier.issn0960-0760 (online)
dc.identifier.otherdoi:10.1016/j.jsbmb.2019.105439
dc.identifier.urihttp://hdl.handle.net/10019.1/110679
dc.language.isoen_ZAen_ZA
dc.publisherElsevier
dc.rights.holderAuthors retain copyright
dc.subjectSteroidsen_ZA
dc.subjectSteroid hormones -- Synthesisen_ZA
dc.subjectUrine -- Analysisen_ZA
dc.subjectSteroidogenesisen_ZA
dc.titleHuman steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive reviewen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
schiffer_human_2019.pdf
Size:
6.87 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Biochemistry)