Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review
Date
2019-07-27
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Advances in technology have allowed for the sensitive, specific, and simultaneous quantitative profiling of
steroid precursors, bioactive steroids and inactive metabolites, facilitating comprehensive characterization of the
serum and urine steroid metabolomes. The quantification of steroid panels is therefore gaining favor over
quantification of single marker metabolites in the clinical and research laboratories. However, although the
biochemical pathways for the biosynthesis and metabolism of steroid hormones are now well defined, a gulf still
exists between this knowledge and its application to the measured steroid profiles. In this review, we present an
overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues, specifically
highlighting the pathways linking and differentiating the serum and urine steroid metabolomes. A brief overview
of the methodology used in steroid profiling is also provided.
Description
CITATION: Schiffer, L. et al. 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review. Journal of Steroid Biochemistry and Molecular Biology, 194:105439, doi:10.1016/j.jsbmb.2019.105439.
The original publication is available at https://www.sciencedirect.com
The original publication is available at https://www.sciencedirect.com
Keywords
Steroids, Steroid hormones -- Synthesis, Urine -- Analysis, Steroidogenesis
Citation
Schiffer, L. et al. 2019. Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes : a comprehensive review. Journal of Steroid Biochemistry and Molecular Biology, 194:105439, doi:10.1016/j.jsbmb.2019.105439.