Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats

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dc.contributor.authorArokoyo, Dennis Seyien_ZA
dc.contributor.authorOyeyipo, Ibukun Peteren_ZA
dc.contributor.authorDu Plessis, Stefan Simonen_ZA
dc.contributor.authorAboua, Yapo Guillaumeen_ZA
dc.date.accessioned2020-12-18T12:53:58Z
dc.date.available2020-12-18T12:53:58Z
dc.date.issued2018
dc.descriptionCITATION: Arokoyo, D. S. et al. 2018. Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats. Pharmacognosy Research, 10:31-6, doi:10.4103/pr.pr_84_17.
dc.descriptionThe original publication is available at https://www.phcogres.com
dc.description.abstractBackground: Oxidative stress is frequently identified as a key element in the pathophysiology of many complications of diabetes mellitus, including reproductive complications. The antioxidant potential of medicinal plants have been suggested for therapeutic focus of diseases in recent reports. Objective: To investigate the effect of Basella alba (Ba) aqueous leave extract on diabetes‑induced oxidative stress. Materials and Methods: Forty male Wistar rats (8–10 weeks) were randomly divided into four groups (n = 10) and treated as follows; Control (C + Ns) and Diabetic (D + Ns) animals received oral normal saline 0.5 ml/100 g body weight daily, while Healthy Treatment (H + Ba) and Diabetic Treatment (D + Ba) rats were given Ba extract at an oral dose of 200 mg/kg body weight daily. Treatment was by gavage and lasted 4 weeks in all groups. Diabetes was induced in D + Ns and D + Ba rats by single intraperitoneal injection of streptozotocin (55 mg/kg) and fasting blood sugar (FBS) recorded weekly in all rats afterwards. Animals were euthanized at the end of the experiment and blood samples, pancreas, testes, and epididymis were preserved for analysis of oxidative stress biomarkers. Results: Oral administration of aqueous leave extract of Ba significantly (P < 0.0001) lowered FBS in D + Ba rats. There was significantly higher blood superoxide dismutase activity and serum ferric reducing antioxidant power, but lower serum concentration of conjugated dienes and thiobarbituric acid reactive substances in D + Ba compared to D + Ns rats (P < 0.05). Conclusion: Ba exerts antioxidant effects in the gonads by enhancing antioxidant parameters in circulating blood, but not necessarily in the gonadal tissues.en_ZA
dc.description.versionPublisher's version
dc.format.extent6 pages
dc.identifier.citationArokoyo, D. S. et al. 2018. Antioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar rats. Pharmacognosy Research, 10:31-6, doi:10.4103/pr.pr_84_17.
dc.identifier.issn0974-8490 (online)
dc.identifier.otherdoi:10.4103/pr.pr_84_17
dc.identifier.urihttp://hdl.handle.net/10019.1/108968
dc.language.isoen_ZAen_ZA
dc.publisherWolters Kluwer
dc.rights.holderAuthors retain copyright
dc.subjectBasella albaen_ZA
dc.subjectAntioxidantsen_ZA
dc.titleAntioxidant activities of Basella alba aqueous leave extract in blood, pancreas, and gonadal tissues of diabetic male Wistar ratsen_ZA
dc.typeArticleen_ZA
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