Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy
dc.contributor.author | Goodman, Megan B. | en_ZA |
dc.contributor.author | Ziskind, Ari | en_ZA |
dc.date.accessioned | 2016-08-19T09:58:52Z | |
dc.date.available | 2016-08-19T09:58:52Z | |
dc.date.issued | 2015-08-21 | |
dc.description | CITATION: Goodman, M. B. & Ziskind, A. 2015. Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy. African Vision and Eye Health, 74(1), Art. #297, doi:10.4102/aveh.v74i1.297. | |
dc.description | The original publication is available at http://www.avehjournal.org | |
dc.description.abstract | Purpose: To determine the sensitivity of spectral domain ocular coherence tomography (SD-OCT) and fundus auto fluorescence (FAF) images as a screening test to detect early changes in the retina prior to the onset of chloroquine retinopathy. Method: The study was conducted using patients taking chloroquine (CQ), referred by the Rheumatology Department to the Ophthalmology Department at Tygerberg Academic Hospital. Group A consisted of 59 patients on CQ for less than 5 years, and Group B consisted of 53 patients on CQ for more than 5 years. A 200 × 200 macula thickness map, 5-line raster SD-OCT on a Carl Zeiss Meditec Cirrus HD-OCT and FAF images on a Carl Zeiss Meditec Visucam 500 were recorded for 223 eyes. Images were reviewed independently, and then those of Groups A and B compared. Results: There were no statistically significant differences between Groups A and B. The criteria included the internal limiting membrane and the retinal pigment epithelium (ILM-RPE) thickness, interdigitation zone integrity (p = 0.891, df = 1, χ² = 0.1876), ellipsoid zone integrity (p = 0.095, df = 2, χ² = 4.699) and FAF image irregularities (p = 0.479, df = 1, χ² = 4995978). Conclusion: The inclusion of SD-OCT and FAF as objective tests into the prescribed screening guidelines does not appear to simplify the detection of subclinical injury in patients on chloroquine treatment. | en_ZA |
dc.description.abstract | AFRIKAANSE OPSOMMING: Geen opsomming beskikbaar | af_ZA |
dc.description.uri | http://www.avehjournal.org/index.php/aveh/article/view/297 | |
dc.description.version | Publisher's version | |
dc.format.extent | 5 pages | en_ZA |
dc.identifier.citation | Goodman, M. B. & Ziskind, A. 2015. Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy. African Vision and Eye Health, 74(1), Art. #297, doi:10.4102/aveh.v74i1.297. | |
dc.identifier.issn | 2410-1516 (online) | |
dc.identifier.issn | 2413-3183 (print) | |
dc.identifier.other | doi:10.4102/aveh.v74i1.297 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/99418 | |
dc.language.iso | en_ZA | en_ZA |
dc.publisher | AOSIS Publishing | en_ZA |
dc.rights.holder | Authors retain copyright | en_ZA |
dc.subject | Chloroquine retinopathy | en_ZA |
dc.subject | Spectral domain ocular coherence tomography | en_ZA |
dc.subject | Retinopathy of prematurity | en_ZA |
dc.subject | Fundus fluorescence photography | en_ZA |
dc.title | Fundus auto fluorescence and spectral domain ocular coherence tomography in the early detection of chloroquine retinopathy | en_ZA |
dc.type | Article | en_ZA |