Presentations, Posters and Papers (Genetics)

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    Regulatory T-cells and high levels of FOXP3 mRNA leads to decreased immune responses in HIV-TB co-infection
    (BioMed Central, 2009-10) Loxton, A.; Roberts, T.; Black, G.; Walzl, G.; Ross, Anna Laura (ed)
    Background Tuberculosis causes 2 million deaths per year and is the most important opportunistic infection in patients infected with HIV. During the co-infection of HIV/TB, natural regulatory T cells (CD4+ FOXP3+) down regulate Th1/Th2 responses. Our study analysed the regulatory Tcell phenotypes amongst participants dually infected with HIV/TB, HIV or TB alone and healthy HIV negative controls and used it as the basis for analysing anti-TB responses and gene expression in HIV infected participants.