Clinical evolution, management and outcomes of patients with COVID-19 admitted at Tygerberg Hospital, Cape Town, South Africa : a research protocol

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dc.contributor.authorAllwood, Brian W.en_ZA
dc.contributor.authorKoegelenberg, Coenraad F. N.en_ZA
dc.contributor.authorIrusen, Elvisen_ZA
dc.contributor.authorLalla, Ushaen_ZA
dc.contributor.authorDavids, Razeenen_ZA
dc.contributor.authorChothia, Yazieden_ZA
dc.contributor.authorDavids, Ryanen_ZA
dc.contributor.authorProzesky, Hansen_ZA
dc.contributor.authorTaljaard, Jantjieen_ZA
dc.contributor.authorParker, Arifaen_ZA
dc.contributor.authorDecloedt, Ericen_ZA
dc.contributor.authorJordan, Portiaen_ZA
dc.contributor.authorLahri, Sa'aden_ZA
dc.contributor.authorMoosa, Rafiqueen_ZA
dc.contributor.authorSchrueder, Neshaaden_ZA
dc.contributor.authorDu Toit, Rietteen_ZA
dc.contributor.authorViljoen, Abrahamen_ZA
dc.contributor.authorEnglish, Reneen_ZA
dc.contributor.authorAyele, Birhanuen_ZA
dc.contributor.authorNyasulu, Peteren_ZA
dc.contributor.authorCOVID-19 Research Response Teamen_ZA
dc.date.accessioned2020-09-14T07:29:50Z
dc.date.available2020-09-14T07:29:50Z
dc.date.issued2020-08-06
dc.descriptionCITATION: Allwood, B. W. et al. 2020. Clinical evolution, management and outcomes of patients with COVID-19 admitted at Tygerberg Hospital, Cape Town, South Africa : a research protocol. BMJ Open, 10:e039455, doi:10.1136/bmjopen-2020-039455.
dc.descriptionThe original publication is available at https://bmjopen.bmj.com
dc.description.abstractIntroduction The outbreak of the SARS-CoV-2 virus causing COVID-19, declared a global pandemic by the WHO, is a novel infection with a high rate of morbidity and mortality. In South Africa, 55 421 cases have been confirmed as of 10 June 2020, with most cases in the Western Cape Province. Coronavirus leaves us in a position of uncertainty regarding the best clinical approach to successfully manage the expected high number of severely ill patients with COVID-19. This presents a unique opportunity to gather data to inform best practices in clinical approach and public health interventions to control COVID-19 locally. Furthermore, this pandemic challenges our resolve due to the high burden of HIV and tuberculosis (TB) in our country as data are scarce. This study endeavours to determine the clinical presentation, severity and prognosis of patients with COVID-19 admitted to our hospital. Methods and analysis The study will use multiple approaches taking into account the evolving nature of the COVID-19 pandemic. Prospective observational design to describe specific patterns of risk predictors of poor outcomes among patients with severe COVID-19 admitted to Tygerberg Hospital. Data will be collected from medical records of patients with severe COVID-19 admitted at Tygerberg Hospital. Using the Cox proportional hazards model, we will investigate the association between the survival time of patients with COVID-19 in relation to one or more of the predictor variables including HIV and TB. Ethics and dissemination The research team obtained ethical approval from the Health Research Ethics Committee of the Faculty of Medicine and Health Sciences, Stellenbosch University and Research Committee of the Tygerberg Hospital. All procedures for the ethical conduct of scientific investigation will be adhered to by the research team. The findings will be disseminated in clinical seminars, scientific forums and conferences targeting clinical care providers and policy-makers.en_ZA
dc.description.versionPublisher's version
dc.format.extent6 pagesen_ZA
dc.identifier.citationAllwood, B. W. et al. 2020. Clinical evolution, management and outcomes of patients with COVID-19 admitted at Tygerberg Hospital, Cape Town, South Africa : a research protocol. BMJ Open, 10:e039455, doi:10.1136/bmjopen-2020-039455.
dc.identifier.issn2044-6055 (online)
dc.identifier.otherdoi:10.1136/bmjopen-2020-039455
dc.identifier.urihttp://hdl.handle.net/10019.1/108822
dc.language.isoen_ZAen_ZA
dc.publisherBMJ Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCOVID-19 (Disease) -- Patients -- Managementen_ZA
dc.subjectSARS-CoV-2 diseaseen_ZA
dc.subjectPublic health administrationen_ZA
dc.subjectClinical epidemiologyen_ZA
dc.titleClinical evolution, management and outcomes of patients with COVID-19 admitted at Tygerberg Hospital, Cape Town, South Africa : a research protocolen_ZA
dc.typeArticleen_ZA
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