Chronic obstructive pulmonary disease (COPD) : neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD

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dc.contributor.authorGuiedem, Eliseen_ZA
dc.contributor.authorIkomey, George Mondindeen_ZA
dc.contributor.authorNkenfou, Celineen_ZA
dc.contributor.authorWalter, Pefura-Yone Ericen_ZA
dc.contributor.authorMesembe, Marthaen_ZA
dc.contributor.authorChegou, Novel N.en_ZA
dc.contributor.authorJacobs, Graeme Brendonen_ZA
dc.contributor.authorOkomo Assoumou, Marie Claireen_ZA
dc.date.accessioned2018-04-03T06:31:02Zen_ZA
dc.date.available2018-04-03T06:31:02Z
dc.date.issued2018-03-27
dc.date.updated2018-04-01T13:19:47Z
dc.descriptionCITATION: Guiedem, E., et al. 2018. Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD. BMC Research Notes, 11:192, doi:10.1186/s13104-018-3309-6.
dc.descriptionThe original publication is available at https://bmcresnotes.biomedcentral.com
dc.description.abstractObjective: The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that of the post tuberculosis form is not yet known. This study aimed to evaluate the levels of neutrophils, macrophages and lymphocytes cells in sputum of COPD patients with history of smoking or anterior tuberculosis. Enumeration of cells in samples was analyzed using standard microscopy. Results: We enrolled 92 participants, 46 (50%) were COPD subjects comprising 22 (47.83%) smokers and 24 (52.17%) with anterior tuberculosis while 46 (50%) healthy persons constituted the control group. The levels of neutrophils, lymphocytes and monocytes were statistically higher in COPD patients compared to the control group with p-values of 0.0001 respectively. Neutrophils levels were higher in COPD patients with history of tobacco than in COPD patients with anterior tuberculosis with a mean rate of 4.72 × 106/ml and 2.48 × 106/ml respectively (p = 0.04). The monocytes and lymphocytes levels were not statistically different between the two sub-groups of COPD patients with p-value of 0.052 and 0.91 respectively. Neutrophils are the only inflammatory cells that were significantly higher in COPD patients with history of smoking as compared to COPD patients with anterior tuberculosis.
dc.description.urihttps://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3309-6
dc.description.versionPublisher's version
dc.format.extent5 pages
dc.identifier.citationGuiedem, E., et al. 2018. Chronic obstructive pulmonary disease (COPD): neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPD. BMC Research Notes, 11:192, doi:10.1186/s13104-018-3309-6
dc.identifier.issn1756-0500 (online)
dc.identifier.otherdoi:10.1186/s13104-018-3309-6
dc.identifier.urihttp://hdl.handle.net/10019.1/103247
dc.language.isoen_ZAen_ZA
dc.publisherBioMed Central
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosisen_ZA
dc.subjectTobaccoen_ZA
dc.subjectLungs -- Diseases, Obstructiveen_ZA
dc.titleChronic obstructive pulmonary disease (COPD) : neutrophils, macrophages and lymphocytes in patients with anterior tuberculosis compared to tobacco related COPDen_ZA
dc.typeArticleen_ZA
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