The gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?

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dc.contributor.authorEribo, Osagieen_ZA
dc.contributor.authordu Plessis, Nelitaen_ZA
dc.contributor.authorOzturk, Muminen_ZA
dc.contributor.authorGuler, Retoen_ZA
dc.date.accessioned2022-04-29T07:23:05Z
dc.date.available2022-04-29T07:23:05Z
dc.date.issued2020-04
dc.descriptionCITATION:Osagie A. Eribo, Nelita du Plessis, Mumin Ozturk, Reto Guler, Gerhard Walzl & Novel N. Chegou Cellular and Molecular Life Sciences volume 77, pages 1497–1509 (2020)
dc.description.abstractAlthough tuberculosis (TB) is a curable disease, it remains the foremost cause of death from a single pathogen. Globally, approximately 1.6 million people died of TB in 2017. Many predisposing factors related to host immunity, genetics and the environment have been linked to TB. However, recent evidence suggests a relationship between dysbiosis in the gut microbiome and TB disease development. The underlying mechanism(s) whereby dysbiosis in the gut microbiota may impact the different stages in TB disease progression, are, however, not fully explained. In the wake of recently emerging literature, the gut microbiome could represent a potential modifiable host factor to improve TB immunity and treatment response. Herein, we summarize early data detailing (1) possible association between gut microbiome dysbiosis and TB (2) the potential for the use of microbiota biosignatures to discriminate active TB disease from healthy individuals (3) the adverse effect of protracted anti-TB antibiotics treatment on gut microbiota balance, and possible link to increased susceptibility to Mycobacterium tuberculosis re-infection or TB recrudescence following successful cure. We also discuss immune pathways whereby the gut microbiome could impact TB disease and serve as target for clinical manipulation.en_ZA
dc.format.extent13 pages
dc.identifier.otherDOI: 10.1007/s00018-019-03370-4
dc.identifier.urihttp://hdl.handle.net/10019.1/124484
dc.language.isoen_ZAen_ZA
dc.rights.holderAuthors retain copyright
dc.subjectGut commensalen_ZA
dc.subjectImmune responseen_ZA
dc.subjectMicrobial imbalanceen_ZA
dc.subjectMicrobiome biosignaturesen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectTuberculosis therapyen_ZA
dc.titleThe gut microbiome in tuberculosis susceptibility and treatment response: guilty or not guilty?en_ZA
dc.typeArticleen_ZA
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