The impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitis

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dc.contributor.authorKruger, Irmaen_ZA
dc.contributor.authorMaritz, Jeanen_ZA
dc.contributor.authorFinlayson, Heatheren_ZA
dc.date.accessioned2020-02-11T09:55:05Z
dc.date.available2020-02-11T09:55:05Z
dc.date.issued2018-10
dc.descriptionCITATION: Kruger, I., Maritz, J. & Finlayson, H. 2018. The impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitis. Southern African Journal of Infectious Diseases, 33(4):101-105, doi:10.4102/sajid.v33i4.157.en_ZA
dc.descriptionThe original publication is available at https://sajid.co.zaen_ZA
dc.description.abstractBackground: Viral meningitis is the most common form of aseptic meningitis and requires minimal investigation and treatment. Polymerase chain reaction (PCR) has become the ‘gold standard’ for identifying viruses in cerebrospinal fluid and can provide rapid results. The objective of the study was to describe the aetiology and epidemiology of viral meningitis at Tygerberg Children’s Hospital, as well as the impact of a positive cerebral spinal fluid (CSF) viral panel on the duration of empiric antibiotic treatment. Methods: This was a retrospective folder review of all children aged between 29 days and 13 years who had a CSF specimen on which a viral analysis was performed from January 1, 2010 to December 31, 2014. Results: A total of 288 specimens were identified from the laboratory database. Seventy-nine specimens were presented for data analysis. Thirty-seven specimens had a positive viral analysis. The median age was 11.3 months (IQR 3.7–49.16 months). The microscopy and chemistry results were similar for the two groups except for the CSF lymphocyte count, which was significantly higher in the group with a positive CSF viral analysis compared to those with a negative CSF viral analysis (median 52 vs. 12 × 106/l, p = 0.005). The most common identified virus was Epstein–Barr virus (EBV) (23%), followed by enterovirus (17%). Children with a positive viral analysis tended to receive antibiotics for longer than those who had negative results (p = 0.223). Conclusion: The addition of CSF viral analysis could be helpful in the management of children with meningitis, but at present appears to have little impact on the length of antibiotic use.en_ZA
dc.description.urihttps://sajid.co.za/index.php/sajid/article/view/157
dc.description.urihttps://sajid.co.za/index.php/sajid/article/view/157
dc.description.versionPublisher's version
dc.format.extent5 pages
dc.identifier.citationKruger, I., Maritz, J. & Finlayson, H. 2018. The impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitis. Southern African Journal of Infectious Diseases, 33(4):101-105, doi:10.4102/sajid.v33i4.157.en_ZA
dc.identifier.issn2313-1810 (online)
dc.identifier.issn2312-0053 (print)
dc.identifier.otherdoi:10.4102/sajid.v33i4.157
dc.identifier.urihttp://hdl.handle.net/10019.1/107466
dc.language.isoen_ZAen_ZA
dc.publisherMedpharm Publicationsen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMeningitis in children -- Diagnosisen_ZA
dc.subjectCerebrospinal fluid -- Examinationen_ZA
dc.subjectAntibioticsen_ZA
dc.subjectMeningitis in children -- Treatmenten_ZA
dc.titleThe impact of cerebrospinal fluid viral analysis on empiric antibiotic use in children admitted to Tygerberg Children’s hospital with suspected meningitisen_ZA
dc.typeArticleen_ZA
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