Methamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging study

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dc.contributor.authorVuletica, Daniellaen_ZA
dc.contributor.authorDupontc, Patricken_ZA
dc.contributor.authorRobertsond, Francesen_ZA
dc.contributor.authorWarwick, James M.en_ZA
dc.contributor.authorZeevaartc, Jan Rijnen_ZA
dc.contributor.authorSteina, Dan J.en_ZA
dc.date.accessioned2020-05-04T12:11:16Z
dc.date.available2020-05-04T12:11:16Z
dc.date.issued2018
dc.descriptionCITATION: Vuletica, D., et al. 2018. Methamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging study. NeuroImage: Clinical, 20:1157-1162, doi:10.1016/j.nicl.2018.10.023.
dc.descriptionThe original publication is available at http://www.sciencedirect.com
dc.description.abstractObjective: Methamphetamine dependence can lead to psychotic symptoms which may be mediated by frontal, striatal, limbic, and thalamic regions. There are few neuroimaging data that allow comparison of individuals with methamphetamine dependence who do, and do not, have psychosis. Two complementary imaging techniques were employed to investigate neurocircuitry associated with methamphetamine dependence with and without psychotic symptoms. Methods: Three groups of participants were recruited: methamphetamine dependent (MAA) (N=11), methamphetamine dependent with psychotic symptoms (MAP) (N=14), and controls (N=14). Resting brain glucose metabolism was measured using [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) and cerebral perfusion was assessed using arterial spin labelling (ASL) magnetic resonance imaging. Results: Methamphetamine abusers (MAA and MAP groups) had decreased glucose metabolism compared to healthy controls in the left insula, left precentral gyrus, and the anterior cingulate cortex. Compared to MAA participants, MAP participants had 1) decreased glucose metabolism in the left precentral gyrus and the left inferior frontal gyrus and 2) increased glucose metabolism in the putamen and pallidum. MAP participants also had increased cerebral perfusion in the right putamen and right pallidum compared to MAA. Conclusion: Findings support the involvement of frontal, striatal, and limbic regions in methamphetamine dependence. Furthermore, they indicate that glucose metabolism and cerebral perfusion in these regions are disrupted in methamphetamine dependent individuals with psychotic symptoms.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S2213158218303334
dc.description.versionPublisher's version
dc.format.extent6 pages
dc.identifier.citationVuletica, D., et al. 2018. Methamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging study. NeuroImage: Clinical, 20:1157-1162, doi:10.1016/j.nicl.2018.10.023
dc.identifier.issn2213-1582 (online)
dc.identifier.otherdoi:10.1016/j.nicl.2018.10.023
dc.identifier.urihttp://hdl.handle.net/10019.1/108522
dc.language.isoen_ZAen_ZA
dc.publisherElsevier
dc.rights.holderAuthors retain copyright
dc.subjectMethamphetamine abuseen_ZA
dc.subjectPsychotropic drugsen_ZA
dc.subjectBrain -- Imagingen_ZA
dc.subjectBrain -- Neuroimagingen_ZA
dc.subjectBrain -- Effect of drugs onen_ZA
dc.subjectNeural circuityen_ZA
dc.titleMethamphetamine dependence with and without psychotic symptoms : a multi-modal brain imaging studyen_ZA
dc.typeArticleen_ZA
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