Obtunding the sympathetic response to intubation : experience at 2 minutes after administration of the test agent in patients with cerebral aneurysms

Simple item page
dc.contributor.authorPayne, K. A.en_ZA
dc.contributor.authorMurray, W. B.en_ZA
dc.contributor.authorOosthuizen, J. H. C.en_ZA
dc.date.accessioned2011-03-18T14:57:24Z
dc.date.available2011-03-18T14:57:24Z
dc.date.issued1988
dc.descriptionCITATION: Payne, K. A., Murray, W. B. & Oosthuizen, J. H. C. 1988. Obtunding the sympathetic response to intubation : experience at 2 minutes after administration of the test agent in patients with cerebral aneurysms. South African Medical Journal, 73:584-586.
dc.descriptionThe original publication is available at http://www.samj.org.za
dc.description.abstractThe sympathetic response to laryngoscopy and intubation was studied in 39 patients who were to undergo surgical clipping of a cerebral aneurysm. Intravascular radial artery pressure and ECG monitoring for ST-segment changes or dysrhythmias were used. Ward blood pressures were controlled on bed rest and labetalol. Induction of anaesthesia was with pentothal 4 mg/kg and suxamethonium 1 mg/kg intravenously. This was followed by one of the following intravenous agents by random choice: alfentanil 30 μg/kg, fentanyl 5 μg/kg, lignocaine 2 mg/kg, and lignocaine 10% spray 2 mg/kg to the larynx. ECG changes at laryngoscopy and intubation were minimal. Intubation produced an immediate increase in blood pressure and pulse rate, maximal at 30-60 seconds, falling rapidly towards normal within 2-3 minutes. Alfentanil was very effective in obtunding this response with stable cardiovascular parameters; fentanyl produced a more variable response; and intravenous lignocaine was less satisfactory. Lignocaine spray was ineffective.
dc.description.versionPublisher’s version
dc.format.extent3 pages
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/7399
dc.language.isoen
dc.publisherHealth & Medical Publishing Group
dc.rights.holderSouth African Medical Journal
dc.subjectAneurysmsen_ZA
dc.titleObtunding the sympathetic response to intubation : experience at 2 minutes after administration of the test agent in patients with cerebral aneurysmsen_ZA
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
payne_obtunding_1988.pdf
Size:
722.85 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
Collections
Research Articles (Anaesthesiology and Critical Care)