Neurodevelopment in perinatally HIV-infected children : a concern for adolescence

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dc.contributor.authorLaughton, Barbaraen_ZA
dc.contributor.authorCornell, Mornaen_ZA
dc.contributor.authorBoivin, Michaelen_ZA
dc.contributor.authorVan Rie, Anneliesen_ZA
dc.date.accessioned2014-07-07T12:32:55Z
dc.date.available2014-07-07T12:32:55Z
dc.date.issued2013-06-18
dc.descriptionCITATION: Laughton, B. et al. 2013. Neurodevelopment in perinatally HIV-infected children : a concern for adolescence. Journal of the International Aids Society, 16:18603, doi:10.7448/IAS.16.1.18603.
dc.descriptionThe original publication is available at http://www.jiasociety.org
dc.description.abstractGlobally, an estimated 3.4 million children are living with HIV, yet little is known about the effects of HIV and antiretroviral treatment (ART) on the developing brain, and the neurodevelopmental and behavioural outcomes of perinatally HIV-infected (PHIV ) adolescents. We reviewed the literature on neurodevelopmental outcomes in PHIV children and adolescents, and summarized the current evidence on behaviour, general cognition, specific domains, hearing and language, school performance and physical disabilities due to neurological problems. Evidence suggests that PHIV children do not perform as well as controls on general cognitive tests, processing speed and visual spatial tasks, and are at much higher risk for psychiatric and mental health problems. Children with AIDS-defining diagnoses are particularly at risk for poorer outcomes. A striking finding is the lack of published data specific to the adolescent age group (10 25 years), particularly from resourceconstrained countries, which have the highest HIV prevalence. In addition, extreme heterogeneity in terms of timing and source of infection, and antiretroviral experience limits our ability to summarize findings of studies and generalize results to other settings. Due to the complex nature of the developing adolescent brain, environmental influences and variation in access to ART, there is an urgent need for research on the longitudinal trajectory of neurodevelopment among children and adolescents perinatally infected with HIV, especially in high burden resource-constrained settings.en_ZA
dc.description.urihttp://www.jiasociety.org/index.php/jias/article/view/18603?search=laughton
dc.description.versionPublisher's version
dc.format.extent11 pages
dc.identifier.citationJournal of the International Aids Society
dc.identifier.citation16
dc.identifier.citation18603
dc.identifier.citationLaughton, B. et al. 2013. Neurodevelopment in perinatally HIV-infected children : a concern for adolescence. Journal of the International Aids Society, 16:18603, doi:10.7448/IAS.16.1.18603.
dc.identifier.issn1758-2652 (online)
dc.identifier.otherdoi:10.7448/IAS.16.1.18603
dc.identifier.urihttp://hdl.handle.net/10019.1/94705
dc.languageen
dc.publisherInternational AIDS Society
dc.rights.holderAuthors retain copyright
dc.subjectPerinatally HIV infecteden_ZA
dc.subjectNeurodevelopmenten_ZA
dc.subjectNewborn infants -- Growthen_ZA
dc.subjectHIV-positive childrenen_ZA
dc.subjectHIV-positive youthen_ZA
dc.subjectAntiretroviral agents -- Side effectsen_ZA
dc.subjectHuman growth -- Effect of drugs onen_ZA
dc.subjectBrain -- Effect of drugs onen_ZA
dc.titleNeurodevelopment in perinatally HIV-infected children : a concern for adolescenceen_ZA
dc.typeArticle
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