Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life

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dc.contributor.authorReikie, Brian A.en_ZA
dc.contributor.authorNaidoo, Shalenaen_ZA
dc.contributor.authorRuck, Candice E.en_ZA
dc.contributor.authorSlogrove, Amy L.en_ZA
dc.contributor.authorDe Beer, Corenaen_ZA
dc.contributor.authorLa Grange, Heleenen_ZA
dc.contributor.authorAdams, Rozanne C. M.en_ZA
dc.contributor.authorHo, Kevinen_ZA
dc.contributor.authorSmolen, Kingaen_ZA
dc.contributor.authorSpeert, David P.en_ZA
dc.contributor.authorCotton, Mark F.en_ZA
dc.contributor.authorPreiser, Wolfgangen_ZA
dc.contributor.authorEsser, Monikaen_ZA
dc.contributor.authorKollmann, Tobias R.en_ZA
dc.date.accessioned2014-07-07T12:26:21Z
dc.date.available2014-07-07T12:26:21Z
dc.date.issued2013-01
dc.descriptionCITATION: Reikie, B. A. et al. 2013. Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Clinical and Vaccine Immunology, 20(1):33–38, doi: 10.1128/CVI.00557-12.
dc.descriptionThe original publication is available at http://cvi.asm.org
dc.description.abstractHIV-exposed but uninfected (HEU) infants born to HIV-infected mothers from areas in the world with a high burden of infectious disease suffer higher infectious morbidity and mortality than their HIV unexposed uninfected (HUU) peers. Vaccination provides protection from infection. The possibility exists that altered response to vaccination contributes to the higher rate of infection in HEU than in HUU infants. While short-term, cross-sectional studies support this notion, it is unclear whether or not HEU infants develop long-term protective immune responses following theWHOextended program on immunization (EPI). Vaccine-specific antibody responses were compared between HEU and HUU infants from 2 weeks until 2 years of age in a longitudinal South African cohort. Total IgG and antibodies specific for Bordetella pertussis, Haemophilus influenzae type b (Hib), tetanus toxoid, hepatitis B virus (HepB), and measles virus were measured at multiple time points throughout the first 2 years of life. Prevaccine antibodies (maternal antibodies passively acquired) specific for tetanus were lower in HEU than in HUU infants, while prevaccine antibodies to HepB were higher in HEU than in HUU infants. Both groups responded similarly to tetanus, Hib, and HepB vaccination. HEU demonstrated stronger pertussis vaccine responses, developing protective titers 1 year earlier than HUU patients, and maintained higher anti-tetanus titers at 24 months of age. Vaccine-induced antibodies to measles virus were similar in both groups at all time points. Our results suggest that the current EPI vaccination program as practiced in South Africa leads to the development of vaccine-specific antibody responses that are equivalent in HEU and HUU infants. However, our data also suggest that a large fraction of both HEU and HUU South African infants have antibody titers for several infectious threats that remain below the level of protection for much of their first 2 years of life.en_ZA
dc.description.urihttp://cvi.asm.org/content/20/1/33.abstract?sid=24f0e5f0-2fcf-4d33-a180-dc6acb659f99
dc.description.versionPublisher's version
dc.format.extent6 pages
dc.identifier.citationReikie, B. A. et al. 2013. Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Clinical and Vaccine Immunology, 20(1):33–38, doi: 10.1128/CVI.00557-12.
dc.identifier.issn1556-679X (online)
dc.identifier.issn1556-6811 (print)
dc.identifier.otherdoi: 10.1128/CVI.00557-12
dc.identifier.urihttp://hdl.handle.net/10019.1/93518
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights.holderAmerican Society for Microbiology
dc.subjectHIV-exposed but uninfected (HEU) infantsen_ZA
dc.subjectAntibodiesen_ZA
dc.subjectChildern of HIV-positive mothers -- Health aspectsen_ZA
dc.subjectVaccination of infants -- Effectivenessen_ZA
dc.subjectInfection in infants -- South Africaen_ZA
dc.titleAntibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of lifeen_ZA
dc.typeArticle
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