The role of a multi-strain probiotic in very low birth weight premature infants

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dc.contributor.advisorvan Niekerk, Evetteen_ZA
dc.contributor.advisorvan Weissenbruch, Mirjamen_ZA
dc.contributor.advisorBulabula, Andyen_ZA
dc.contributor.authorSowden, Marwynen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Global Health. Human Nutrition.en_ZA
dc.date.accessioned2024-01-15T09:27:26Z
dc.date.accessioned2024-04-26T23:28:40Z
dc.date.available2024-01-15T09:27:26Z
dc.date.available2024-04-26T23:28:40Z
dc.date.issued2024-03
dc.descriptionThesis (PhD)--Stellenbosch University, 2024. en_ZA
dc.description.abstractENGLISH SUMMARY: Background: Researchers have established that the preterm neonate is born with an immature gastrointestinal tract. The preterm neonate is thus susceptible to various complications often seen in the neonatal intensive care unit, e.g. feeding intolerances, necrotising enterocolitis, and hospital-acquired bloodstream infections. These complications can be life-threatening, and if survived, can have an unfavorable effect on the neonate’s growth and development. Aim: The aims of this narrative review article were to provide an in-depth understanding of the various factors contributing to the development of the preterm neonatal microbiome. Further, we reviewed gastrointestinal microbiome dysbiosis and its potential role in the development of feeding intolerances, necotising enterocolitis, and hospital-acquired bloodstream infections. Lastly, we described the potential role of probiotics in this vulnerable population. Methods: A PubMed database search was conducted identifying articles that describe the development and function of the neonatal microbiome, the role of gastrointestinal dysbiosis, and the development of neonatal complications as well as the role of probiotics in gastrointestinal dysbiosis. Results: Various maternal, neonatal, and environmental factors play a role in the development of gastrointestinal dysbiosis in the preterm neonate. This can lead to feeding intolerances, necrotising enterocolitis, and hospital-acquired bloodstream infections. Discussion: The pathogenesis of the development of short-term complications in the preterm neonate can be linked to the immaturity of the host immune system as well as alterations seen in the intestinal microbiome. There is a growing body of evidence that probiotics can play a role in preventing dysbiosis and thus complications observed in the preterm neonate. However, the optimal combination of probiotic strains and dosage still needs to be identified.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Geen opsomming beskikbaar.af_ZA
dc.description.versionDoctorate
dc.format.extent144 pages : illustrations, includes annexures
dc.identifier.urihttps://scholar.sun.ac.za/handle/10019.1/130599
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch University
dc.rights.holderStellenbosch University
dc.subject.lcshGastrointestinal system -- Diseasesen_ZA
dc.subject.lcshIntestines -- Microbiologyen_ZA
dc.subject.lcshPremature infants -- Developmenten_ZA
dc.subject.lcshNeonatal intensive careen_ZA
dc.subject.nameUCTD
dc.titleThe role of a multi-strain probiotic in very low birth weight premature infants en_ZA
dc.typeThesisen_ZA
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Doctoral Degrees (Human Nutrition)