Treatment with Sutherlandia frutescens ssp. microphylla alters the corticosterone response to chronic intermittent immobilization stress in rats

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dc.contributor.authorSmith Carineen_ZA
dc.contributor.authorMyburgh, Kathryn H.en_ZA
dc.date.accessioned2011-05-15T15:55:17Z
dc.date.available2011-05-15T15:55:17Z
dc.date.issued2004
dc.descriptionCITATION: Smith C. & Myburgh, K. H. 2004. Treatment with Sutherlandia frutescens ssp. microphylla alters the corticosterone response to chronic intermittent immobilization stress in rats. South African Journal of Science, 100(3-4):229-232.en_ZA
dc.descriptionThe original publication is available at https://journals.co.za/content/sajscien_ZA
dc.description.abstractMuch anecdotal evidence suggests a stress-relieving effect of the Sutherlandia frutescens herb. We investigated this in a model of chronic intermittent immobilization stress in 40 adult male Wistar rats. A warm water extract of Sutherlandia leaves (4 mg/ml) was used as treatment and isotonic saline as placebo, both injected intraperitoneally. The four experimental groups were: a) control + treatment (CS); b) control + placebo (CP); c) immobilization + treatment (IS) and d) immobilization + placebo (IP). After 28 days, resting blood corticosterone, testosterone, interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were measured. Data were analysed with two-way ANOVA. Immobilization stress resulted in significantly increased corticosterone concentrations in IP vs CP (81 ± 11 vs 22 ±7 ng/ml, P < 0.001), whereas corticosterone concentrations were significantly decreased in IS (43 ± 14 ng/ml, P < 0.05) compared to IP. The two Sutherlandia-treated groups did not differ (CS 57 ± 11 ng/ml). Neither testosterone nor IL-6 and TNF-α concentrations were significantly different among groups. In summary, our data show that Sutherlandia frutescens treatment effectively decreased the corticosterone response to chronic stress, thereby scientifically confirming the indigenous wisdom.en_ZA
dc.description.urihttps://journals.co.za/content/sajsci/100/3-4/EJC96228
dc.description.versionPublisher's versionen_ZA
dc.format.extent4 pages : illustrationsen_ZA
dc.identifier.citationSmith C. & Myburgh, K. H. 2004. Treatment with Sutherlandia frutescens ssp. microphylla alters the corticosterone response to chronic intermittent immobilization stress in rats. South African Journal of Science, 100(3-4):229-232en_ZA
dc.identifier.issn1996-7489 (online)
dc.identifier.issn0038-2353 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/9686
dc.language.isoen_ZAen_ZA
dc.publisherAcademy of Science of South Africaen_ZA
dc.rights.holderAcademy of Science for South Africaen_ZA
dc.subjectRattus norvegicusen_ZA
dc.subjectSutherlandia frutescens treatmenten_ZA
dc.subjectRats as laboratory animalsen_ZA
dc.subjectCorticosterone response in ratsen_ZA
dc.titleTreatment with Sutherlandia frutescens ssp. microphylla alters the corticosterone response to chronic intermittent immobilization stress in ratsen_ZA
dc.typeArticleen_ZA
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