Modulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats

Simple item page
dc.contributor.authorMarnewick, J. L.
dc.contributor.authorJoubert, E.
dc.contributor.authorSwart, P.
dc.contributor.authorDer Westhuizen, F. V.
dc.contributor.authorGelderblom, W. C.
dc.date.accessioned2011-05-15T15:56:52Z
dc.date.available2011-05-15T15:56:52Z
dc.date.issued2003
dc.description.abstractRooibos and honeybush teas significantly (P < 0.05) enhanced the activity of cytosolic glutathione S-transferase alpha. A significant (P < 0.05) to marginal (P < 0.1) increase in the activity of the microsomal UDP-glucuronosyl transferase was obtained with unprocessed rooibos and honeybush teas, respectively. Oxidized glutathione (GSSG) levels were significantly (P < 0.05) reduced in the liver of all tea treated rats while reduced glutathione (GSH) was markedly increased in the liver of the herbal tea treated rats. These changes resulted in a significant (P < 0.05) increase in the GSH/GSSG ratio by the unprocessed, processed rooibos and unprocessed honeybush teas. Green and black teas markedly to significantly decreased the oxygen radical absorbance capacity in liver homogenates, respectively. Modulation of phase II drug metabolizing enzymes and oxidative status in the liver may be important events in the protection against adverse effects related to mutagenesis and oxidative damage.
dc.description.versionArticle
dc.identifier.citationJournal of Agricultural and Food Chemistry
dc.identifier.citation51
dc.identifier.citation27
dc.identifier.issn218561
dc.identifier.other10.1021/jf0344643
dc.identifier.urihttp://hdl.handle.net/10019.1/10087
dc.subjectdrug metabolizing enzyme
dc.subjectglucuronosyltransferase
dc.subjectglutathione
dc.subjectglutathione disulfide
dc.subjectglutathione transferase
dc.subjectliver enzyme
dc.subjectoxygen radical
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdrug metabolism
dc.subjectenzyme activity
dc.subjectenzyme assay
dc.subjectherbal medicine
dc.subjecthoneybush
dc.subjectliver
dc.subjectliver cytosol
dc.subjectliver homogenate
dc.subjectliver metabolism
dc.subjectliver microsome
dc.subjectmale
dc.subjectmodulation
dc.subjectmutagenesis
dc.subjectnonhuman
dc.subjectoxidation
dc.subjectprocessing
dc.subjectrat
dc.subjectrooibos
dc.subjectstatistical significance
dc.subjecttea
dc.subjectAnimals
dc.subjectAspalathus
dc.subjectBeverages
dc.subjectCamellia sinensis
dc.subjectFabaceae
dc.subjectFlavonoids
dc.subjectGlucuronosyltransferase
dc.subjectGlutathione
dc.subjectGlutathione Transferase
dc.subjectLiver
dc.subjectMale
dc.subjectOxidation-Reduction
dc.subjectPhenols
dc.subjectRats
dc.subjectRats, Inbred F344
dc.subjectReactive Oxygen Species
dc.subjectTea
dc.subjectAnimalia
dc.subjectAspalathus
dc.subjectAspalathus linearis
dc.subjectCamellia
dc.subjectCamellia sinensis
dc.subjectCyclopia
dc.titleModulation of Hepatic Drug Metabolizing Enzymes and Oxidative Status by Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia), Green and Black (Camellia sinensis) Teas in Rats
dc.typeArticle
Files
Collections
Stellenbosch University - Scopus Publications