Towards establishing capacity for biological dosimetry at Ghana atomic energy commission

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dc.contributor.authorAchel, Daniel Gyingirien_ZA
dc.contributor.authorAchoribo, Elomen_ZA
dc.contributor.authorAgbenyegah, Sandraen_ZA
dc.contributor.authorAdaboro, Rudolph M.en_ZA
dc.contributor.authorDonkor, Shadracken_ZA
dc.contributor.authorAdu-Bobi, Nana A. K.en_ZA
dc.contributor.authorAgyekum, Akwasi A.en_ZA
dc.contributor.authorAkuamoa, Feliciaen_ZA
dc.contributor.authorTagoe, Samuel N.en_ZA
dc.contributor.authorKyei, Kofi A.en_ZA
dc.contributor.authorYarney, Joelen_ZA
dc.contributor.authorSerafin, Antonioen_ZA
dc.contributor.authorAkudugu, John M.en_ZA
dc.date.accessioned2017-08-15T12:37:09Z
dc.date.available2017-08-15T12:37:09Z
dc.date.issued2016
dc.descriptionCITATION: Achel, Daniel G., et al. 2016. Towards establishing capacity for biological dosimetry at Ghana atomic energy commission. Genome Integrity, 7(1):1-5, doi:10.4103/2041-9414.197173.
dc.descriptionThe original publication is available at http://www.genome-integrity.org
dc.description.abstractENGLISH SUMMARY : The aim of this study was not only to obtain basic technical prerequisites for the establishment of capacity of biological dosimetry at the Ghana Atomic Energy Commission (GAEC) but also to stimulate interest in biological dosimetry research in Ghana and Sub-Saharan Africa. Peripheral blood from four healthy donors was exposed to different doses (0–6 Gy) of gamma rays from a radiotherapy machine and lymphocytes were subsequently stimulated, cultured, and processed according to standard protocols for 48–50 h. Processed cells were analyzed for the frequencies of dicentric and centric ring chromosomes. Radiation dose delivered to the experimental model was verified using GafChromic® EBT films in parallel experiments. Basic technical prerequisites for the establishment of capacity of biological dosimetry in the GAEC have been realized and expertise in the dicentric chromosome assay consolidated. We successfully obtained preliminary cytogenetic data for a dose-response relationship of the irradiated blood lymphocytes. The data strongly indicate the existence of significant linear (α) and quadratic (β) components and are consistent with those published for the production of chromosome aberrations in comparable absorbed dose ranges.en_ZA
dc.description.urihttp://www.genome-integrity.org/article.asp?issn=2041-9414;year=2016;volume=7;issue=1;spage=3;epage=3;aulast=Achel
dc.description.versionPublisher's version
dc.format.extent5 pages ; illustrations
dc.identifier.citationAchel, Daniel G., et al. 2016. Towards establishing capacity for biological dosimetry at Ghana atomic energy commission. Genome Integrity, 7(1):1-5, doi:10.4103/2041-9414.197173
dc.identifier.issn2041-9414 (online)
dc.identifier.otherdoi:10.4103/2041-9414.197173
dc.identifier.urihttp://hdl.handle.net/10019.1/102108
dc.language.isoen_ZAen_ZA
dc.publisherMedknow Publications
dc.rights.holderAuthors retain copyright
dc.subjectRadiation dosimetry -- Research – Ghanaen_ZA
dc.subjectRadiation -- Measurement -- Ghanaen_ZA
dc.subjectRadiation -- Dose-response relationshipen_ZA
dc.subjectGhana Atomic Energy Commissionen_ZA
dc.subjectHuman chromosome abnormalities -- Ghanaen_ZA
dc.titleTowards establishing capacity for biological dosimetry at Ghana atomic energy commissionen_ZA
dc.typeArticleen_ZA
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