Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration

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dc.contributor.authorMazibuko-Mbeje, Sithandiwe E.en_ZA
dc.contributor.authorDludla, Phiwayinkosi V.en_ZA
dc.contributor.authorJohnson, Rabiaen_ZA
dc.contributor.authorJoubert, Elizabethen_ZA
dc.contributor.authorLouw, Johanen_ZA
dc.contributor.authorZiqubu, Khanyisanien_ZA
dc.contributor.authorTiano, Lucaen_ZA
dc.contributor.authorSilvestri, Soniaen_ZA
dc.contributor.authorOrlando, Patricken_ZA
dc.contributor.authorOpoku, Andy R.en_ZA
dc.contributor.authorMuller, Christo J. F.en_ZA
dc.date.accessioned2021-09-28T12:37:40Z
dc.date.available2021-09-28T12:37:40Z
dc.date.issued2019
dc.descriptionCITATION: Mazibuko-Mbeje, S. E., et al. 2019. Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration. PLoS ONE, 14(5):e0216172, doi:10.1371/journal.pone.0216172.
dc.descriptionThe original publication is available at https://journals.plos.org/plosone/
dc.description.abstractENGLISH ABSTRACT: Aspalathin is a rooibos flavonoid with established blood glucose lowering properties, however, its efficacy to moderate complications associated with hepatic insulin resistance is unknown. To study such effects, C3A liver cells exposed to palmitate were used as a model of hepatic insulin resistance. These hepatocytes displayed impaired substrate metabolism, including reduced glucose transport and free fatty acid uptake. These defects included impaired insulin signaling, evident through reduced phosphatidylinositol-4,5-bisphosphate 3-kinase/ protein kinase B (PI3K/AKT) protein expression, and mitochondrial dysfunction, depicted by a lower mitochondrial respiration rate. Aspalathin was able to ameliorate these defects by correcting altered substrate metabolism, improving insulin signaling and mitochondrial bioenergetics. Activation of 5ยด-adenosine monophosphate-activated protein kinase (AMPK) may be a plausible mechanism by which aspalathin increases hepatic energy expenditure. Overall, these results encourage further studies assessing the potential use of aspalathin as a nutraceutical to improve hepatocellular energy expenditure, and reverse metabolic disease-associated complications.en_ZA
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216172
dc.description.versionPublisher's version
dc.format.extent16 pagesen_ZA
dc.identifier.citationMazibuko-Mbeje, S. E., et al. 2019. Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration. PLoS ONE, 14(5):e0216172, doi:10.1371/journal.pone.0216172
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0216172
dc.identifier.urihttp://hdl.handle.net/10019.1/123089
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectObesityen_ZA
dc.subjectInsulin resistanceen_ZA
dc.subjectEnergy metabolismen_ZA
dc.subjectAspalathinen_ZA
dc.subjectMitochondrial disordersen_ZA
dc.titleAspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respirationen_ZA
dc.typeArticleen_ZA
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