Cellular radiosensitivity : do separate predictive parameters apply for fibroblasts and for human tumour cells?
Date
2004
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Nature
Abstract
A paper by El-Awady et al, 2003 brings to the fore new evidence for correlations between radiosensitivity and the initial DNA damage in the form of double-strand breaks (dsb). The conclusion is at variance with a previous paper by the same group where the nonrepaired DNA dsb were identified as indicators of radiosensitivity (Dikomey et al, 1998). Both studies use constant field gel electrophoresis (CFGE) and a modification called graded field gel electrophoresis (GFGE) that detects mobile low molecular weight DNA fragments generated by large single doses of irradiation in the range of 20–100 Gy (Dahm-Daphi and Dikomey, 1995).
Description
CITATION: Bohm, L. 2004. Cellular radiosensitivity : do separate predictive parameters apply for fibroblasts and for human tumour cells? British Journal of Cancer, 90:554–555.
The original publication is available at https://www.nature.com
The original publication is available at https://www.nature.com
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Citation
Bohm, L. 2004. Cellular radiosensitivity : do separate predictive parameters apply for fibroblasts and for human tumour cells? British Journal of Cancer, 90:554–555.