Coenzyme Q10 supplementation improves adipokine levels and alleviates inflammation and lipid peroxidation in conditions of metabolic syndrome : a meta-analysis of randomized controlled trials

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dc.contributor.authorDludla, Phiwayinkosi V.en_ZA
dc.contributor.authorOrlando, Patricken_ZA
dc.contributor.authorSilvestri, Soniaen_ZA
dc.contributor.authorMarcheggiani, Fabioen_ZA
dc.contributor.authorCirilli, Ileniaen_ZA
dc.contributor.authorNyambuya, Tawanda M.en_ZA
dc.contributor.authorMxinwa, Vuyolwethuen_ZA
dc.contributor.authorMokgalaboni, Kabeloen_ZA
dc.contributor.authorNkambule, Bongani B.en_ZA
dc.contributor.authorJohnson, Rabiaen_ZA
dc.contributor.authorMazibuko-Mbeje, Sithandiwe E.en_ZA
dc.contributor.authorMuller, Christo J. F.en_ZA
dc.contributor.authorLouw, Johanen_ZA
dc.contributor.authorTiano, Lucaen_ZA
dc.date.accessioned2022-09-20T10:55:27Zen_ZA
dc.date.available2022-09-20T10:55:27Zen_ZA
dc.date.issued2020-05-04en_ZA
dc.descriptionCITATION: Dludla, P. V., et al. 2020. Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences. 2020; 21(9). doi:10.3390/ijms21093247en_ZA
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/ijmsen_ZA
dc.description.abstractEvidence from randomized controlled trials (RCTs) suggests that coenzyme Q10 (CoQ10) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible RCTs reporting on any correlation between adipokine levels and modulation of inflammation and oxidative stress in individuals with metabolic syndrome taking CoQ10. The risk of bias was assessed using the modified Black and Downs checklist, while the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to evaluate the quality of evidence. Results from the current meta-analysis, involving 318 participants, showed that CoQ10 supplementation in individuals with metabolic syndrome increased adiponectin levels when compared to those on placebo (SMD: 1.44 [95% CI: −0.13, 3.00]; I2 = 96%, p < 0.00001). Moreover, CoQ10 supplementation significantly lowered inflammation markers in individuals with metabolic syndrome in comparison to those on placebo (SMD: −0.31 [95% CI: −0.54, −0.08]; I2 = 51%, p = 0.07). Such benefits with CoQ10 supplementation were related to its ameliorative effects on lipid peroxidation by reducing malondialdehyde levels, concomitant to improving glucose control and liver function. The overall findings suggest that optimal regulation of adipokine function is crucial for the beneficial effects of CoQ10 in improving metabolic health.en_ZA
dc.description.urihttps://www.mdpi.com/1422-0067/21/9/3247/htmen_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent14 pagesen_ZA
dc.identifier.issn1422-0067 (online)en_ZA
dc.identifier.issn1661-6596 (print)en_ZA
dc.identifier.otherdoi:10.3390/ijms21093247en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125739en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectCoenzyme Q10en_ZA
dc.subjectUbiquinoneen_ZA
dc.subjectMetabolic syndromeen_ZA
dc.subjectMetabolic complicationsen_ZA
dc.subjectNon-alcoholic fatty liver diseaseen_ZA
dc.subjectHypertensionen_ZA
dc.subjectAdipokinesen_ZA
dc.subjectInflammationen_ZA
dc.subjectOxidative stressen_ZA
dc.titleCoenzyme Q10 supplementation improves adipokine levels and alleviates inflammation and lipid peroxidation in conditions of metabolic syndrome : a meta-analysis of randomized controlled trialsen_ZA
dc.typeArticleen_ZA
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