Methylprednisolone and the adult respiratory distress syndrome

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dc.contributor.authorDu Toit, H. J.
dc.contributor.authorErasmus, F. R.
dc.contributor.authorMacFarlane, C. M.
dc.contributor.authorTaljaard, J. J. F.
dc.contributor.authorKing, J. B.
dc.contributor.authorDe Klerk, A. J.
dc.contributor.authorElk, E.
dc.date.accessioned2011-03-18T14:59:45Z
dc.date.available2011-03-18T14:59:45Z
dc.date.issued1984-06
dc.descriptionThe original publication is available at http://archive.samj.org.za/en_ZA
dc.description.abstractTotal hip replacement was carried out on 22 patients under general anaesthesia. Of these, 10 were pretreated with methylprednisolone (30 mg/kg); 1 of these developed the adult respiratory distress syndrome (ARDS) and had high levels of thromboxane B2 (TXB2) 5 minutes after fixation of the femoral prosthesis and at the end of the operation. The other 12 patients served as controls; 5 of them developed ARDS and had statistically significant higher TXB2 levels than the other 7 control patients who remained well. All patients who did not develop ARDS had low TXB2 levels. TXB2 and β-thromboglobulin levels followed the same trend and there was good correlation (r = 0.6806; P < 0.01) at the end of the operation in the control group patients who developed ARDS. There was no statistical difference in 6-keto-PGF(1α) levels between the patients who developed ARDS and those in the control group who remained well. Steroids reduce arachidonic acid metabolism by inhibiting the release of substrate for cyclo-oxygenase and lipoxygenase activity. Patients prone to ARDS thus benefit from methylprednisolone administration.en_ZA
dc.description.versionPublishers' version
dc.format.extentp. 1049-1053 : ill.
dc.identifier.citationDu Toit, H.J. et al. 1984. Methylprednisolone and the adult respiratory distress syndrome. SA mediese tydskrif, 65(26):1049-1053
dc.identifier.issn2078-5135 (online)
dc.identifier.issn0256-9574 (print)
dc.identifier.urihttp://hdl.handle.net/10019.1/8031
dc.publisherOpen access journalen_ZA
dc.publisherHMPG
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMethylprednisoloneen_ZA
dc.subjectTotal hip replacementen_ZA
dc.subjectAnesthesiaen_ZA
dc.subjectRespiratory distress syndromeen_ZA
dc.titleMethylprednisolone and the adult respiratory distress syndromeen_ZA
dc.typeArticleen
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