Mechanical debridement with antibiotics in the treatment of chronic periodontitis : effect on systemic biomarkers - a systematic review

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dc.contributor.authorMunasur, Sudhir L.en_ZA
dc.contributor.authorTurawa, Eunice B.en_ZA
dc.contributor.authorChikte, Usuf M. E.en_ZA
dc.contributor.authorMusekiwa, Alfreden_ZA
dc.date.accessioned2021-04-22T12:51:08Z
dc.date.available2021-04-22T12:51:08Z
dc.date.issued2020
dc.descriptionCITATION: Munasur, S. L., et al. 2020. Mechanical debridement with antibiotics in the treatment of chronic periodontitis : effect on systemic biomarkers - a systematic review. International Journal of Environmental Research and Public Health, 17(15):5601, doi:10.3390/ijerph17155601.
dc.descriptionThe original publication is available at http://www.mdpi.com
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund
dc.description.abstractIn this systematic review, we assessed the effectiveness of systemic antibiotics as an adjunctive therapy to mechanical debridement in improving inflammatory systemic biomarkers, as compared to mechanical debridement alone, among adults with chronic periodontitis. We searched relevant electronic databases for eligible randomized controlled trials. Two review authors independently screened, extracted data, and assessed risk of bias. We conducted meta-analysis, assessed heterogeneity, and assessed certainty of evidence using GRADEPro software. We included 19 studies (n = 1350 participants), representing 18 randomized controlled trials and found very little or no impact of antibiotics on inflammatory biomarkers. A meta-analysis of eight studies demonstrated a mean reduction of 0.26 mm in the periodontal pockets at three months (mean difference [MD] −0.26, 95%CI: −0.36 to −0.17, n = 372 participants, moderate certainty of evidence) in favor of the antibiotics. However, results from five studies reporting clinical attachment level (mm) yielded little or no difference at three months (MD −0.16, 95% CI: −0.35 to 0.03, n = 217 participants) between antibiotic and placebo groups. There is little or no evidence that adjunctive systemic antibiotics therapy improves inflammatory systemic biomarkers, compared to mechanical debridement alone, among adults with chronic periodontitis.en_ZA
dc.description.urihttps://www.mdpi.com/1660-4601/17/15/5601
dc.description.versionPublisher's version
dc.format.extent19 pages ; illustrationsen_ZA
dc.identifier.citationMunasur, S. L., et al. 2020. Mechanical debridement with antibiotics in the treatment of chronic periodontitis : effect on systemic biomarkers - a systematic review. International Journal of Environmental Research and Public Health, 17(15):5601, doi:10.3390/ijerph17155601
dc.identifier.issn1660-4601 (online)
dc.identifier.issn1661-7827 (print)
dc.identifier.otherdoi:10.3390/ijerph17155601
dc.identifier.urihttp://hdl.handle.net/10019.1/110341
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain copyright
dc.subjectPeriodontitis -- Treatmenten_ZA
dc.subjectPericementitisen_ZA
dc.subjectPeriodontium -- Inflammationen_ZA
dc.subjectMechanical debridementen_ZA
dc.subjectDebridementen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectSystematic reviews (Medical research)en_ZA
dc.subjectAntibiotics -- Effectivenessen_ZA
dc.titleMechanical debridement with antibiotics in the treatment of chronic periodontitis : effect on systemic biomarkers - a systematic reviewen_ZA
dc.typeArticleen_ZA
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