Human metapneumovirus infection in hospital referred South African children

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dc.contributor.authorIjpma, F. F. A.
dc.contributor.authorBeekhuis, D.
dc.contributor.authorCotton, M. F.
dc.contributor.authorPieper, C. H.
dc.contributor.authorKimpen, J. L. L.
dc.contributor.authorVan Den Hoogen, B. G.
dc.contributor.authorVan Doornum, G. J. J.
dc.contributor.authorOsterhaus, D. M. E.
dc.date.accessioned2011-05-15T16:17:03Z
dc.date.available2011-05-15T16:17:03Z
dc.date.issued2004
dc.description.abstractHuman metapneumovirus (hMPV) was first described in Dutch children with acute respiratory symptoms. A prospective analysis of the epidemiology, clinical manifestation, and seroprevalence of hMPV and other respiratory viruses in South African children referred to hospital for upper or lower respiratory tract infection were carried out during a single winter season, by using RT-PCR, viral culture, and enzyme-linked immunosorbent assays. In nasopharyngeal aspirates from 137 children, hMPV was detected by RT-PCR in 8 (5.8%) children (2-43 months of age) as a sole viral pathogen, respiratory syncytial virus (RSV) in 21 (15%), influenza A virus in 18 (13%) and influenza B virus in 20 (15%). Pneumonia was diagnosed in seven children and upper respiratory tract infection in one of the hMPV-infected children. One hMPV-infected child was admitted to the intensive care unit in need of mechanical ventilation and one child was infected with human immunodeficiency virus (HIV). No statistically significant differences were found between hMPV, RSV, and influenza virus infected groups with regard to clinical signs and symptoms and chest radiograph findings. The seropositive rate of hMPV specific IgG antibodies was 92% in children aged 24-36 months, the oldest seronegative child in our study was 7 years and 6 months of age. In conclusion, hMPV contributes to upper and lower respiratory tract morbidity in South African children. © 2004 Wiley-Liss, Inc.
dc.description.versionArticle
dc.identifier.citationJournal of Medical Virology
dc.identifier.citation73
dc.identifier.citation3
dc.identifier.issn01466615
dc.identifier.other10.1002/jmv.20116
dc.identifier.urihttp://hdl.handle.net/10019.1/14048
dc.subjectC reactive protein
dc.subjectimmunoglobulin G antibody
dc.subjectarticle
dc.subjectartificial ventilation
dc.subjectchild
dc.subjectclinical feature
dc.subjectdot hybridization
dc.subjectenzyme immunoassay
dc.subjectenzyme linked immunosorbent assay
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjectHuman immunodeficiency virus infection
dc.subjectHuman metapneumovirus
dc.subjectimmunofluorescence
dc.subjectinfant
dc.subjectInfluenza virus A
dc.subjectInfluenza virus B
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmorbidity
dc.subjectpneumonia
dc.subjectRespiratory syncytial pneumovirus
dc.subjectreverse transcription polymerase chain reaction
dc.subjectseroprevalence
dc.subjectSouth Africa
dc.subjectthorax radiography
dc.subjectupper respiratory tract infection
dc.subjectvirus culture
dc.subjectvirus genome
dc.subjectvirus infection
dc.subjectAdolescent
dc.subjectAntibodies, Viral
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHIV
dc.subjectHumans
dc.subjectImmunoglobulin G
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectInfluenza A virus
dc.subjectInfluenza B virus
dc.subjectMale
dc.subjectMetapneumovirus
dc.subjectNasopharynx
dc.subjectParamyxoviridae Infections
dc.subjectPneumonia, Viral
dc.subjectProspective Studies
dc.subjectRespiratory Syncytial Viruses
dc.subjectRespiratory Tract Infections
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectRNA, Viral
dc.subjectSeroepidemiologic Studies
dc.subjectSouth Africa
dc.subjectHuman immunodeficiency virus
dc.subjectHuman metapneumovirus
dc.subjectInfluenza A virus
dc.subjectInfluenza B virus
dc.subjectInfluenza virus
dc.subjectMetapneumovirus
dc.subjectRespiratory syncytial virus
dc.subjectRice stripe virus
dc.titleHuman metapneumovirus infection in hospital referred South African children
dc.typeArticle
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