Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism

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dc.contributor.authorDoruyter, Alexander G.
dc.contributor.authorHartley, Tharbit
dc.contributor.authorAmeyo, Jonathan W.
dc.contributor.authorDavids, M. R.
dc.contributor.authorWarwick, James M.
dc.date.accessioned2014-08-11T14:50:28Z
dc.date.available2014-08-11T14:50:28Z
dc.date.issued2014-03
dc.descriptionDoruyter, A.G. et al. 2014. Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism. Nuclear Medicine Communications, 35(8):884-889, doi:10.1097/MNM.0000000000000131.en_ZA
dc.descriptionThe original publication is available at http://journals.lww.com/nuclearmedicinecomm/pages/default.aspxen_ZA
dc.descriptionFor the university, the copy is available via the OVID platformen_ZA
dc.description.abstractBackground Preoperative localization of parathyroid lesions is potentially beneficial in renal patients with hyperparathyroidism. The aim of this study was to determine the localizing value of hybrid single-photon emission computed tomography combined with low-dose x-ray computed tomography (SPECT/LDCT) compared with SPECT alone and whether the LDCT improved reader confidence. Patients and methods A retrospective study examined parathyroid scintigraphy results of patients previously referred with a diagnosis of renal hyperparathyroidism. All patients underwent planar scintigraphy using technetium- 99m (99mTc)-pertechnetate, which was immediately followed with 99mTc-sestamibi and SPECT/LDCT ∼ 60 min after sestamibi injection and a delayed static image to assess differential washout. Planar subtraction images were generated. Two nuclear physicians, assisted by a radiologist, reported on planar+SPECT images followed by planar+SPECT/LDCT images. Results Thirty-seven patients (males: 21; females: 16) were included (mean age 39 years, range: 23.9–55.5). Mean creatinine level was 878 μmol/l (109–1839), mean corrected calcium level was 2.42 mmol/l (1.77–3.64), and median parathyroid hormone level was 156.2 pmol/l (2.4 to >201). Twenty-three patients had positive planar and SPECTen_ZA
dc.description.versionPost-printen_ZA
dc.format.extent13 p. : ill.
dc.identifier.citationDoruyter, A.G. et al. 2014. Hybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidism. Nuclear Medicine Communications, 35(8):884-889, doi:10.1097/MNM.0000000000000131.en_ZA
dc.identifier.issn1473-5628 (online)
dc.identifier.issn0143-363 (print)
dc.identifier.orcidORCID 0000-0003-4900-0231
dc.identifier.otherdoi:10.1097/MNM.0000000000000131
dc.identifier.urihttp://hdl.handle.net/10019.1/95537
dc.language.isoen_ZAen_ZA
dc.publisherLippincott, Williams & Wilkinsen_ZA
dc.rights.holderLippincott, Williams & Wilkinsen_ZA
dc.subjectParathyroid glands -- Imagingen_ZA
dc.subjectSingle-photon emission computed tomographyen_ZA
dc.subjectParathyroid glands -- Tomographyen_ZA
dc.titleHybrid imaging using low-dose, localizing computed tomography enhances lesion localization in renal hyperparathyroidismen_ZA
dc.typeArticleen_ZA
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