Evidence of hyperinsulinaemia and hypoxaemia in the cord blood of neonates born to mothers with gestational diabetes
Date
1985
Authors
MacFarlane C.M.
Tsakalakos N.
Journal Title
Journal ISSN
Volume Title
Publisher
HMPG
Abstract
Increased cord blood C-peptide levels in neonates born to mothers with gestational diabetes (GD) were directly correlated with the increased relative birth weight ratio (BWR) of these neonates. In addition, the percentage oxygen saturation of the cord blood was inversely correlated with cord blood C-peptide levels and with the relative BWR. These correlations were absent in neonates delivered to normal mothers. The results indicate the presence of both hyperinsulinaemia and mild hypoxaemia in neonates of mothes with GD. In poorly controlled diabetic pregnancy this hypoxaemia may constitute an important fetal risk factor.
Description
Article
The original publication is available at http://www.samj.org.za
The original publication is available at http://www.samj.org.za
Keywords
c peptide, Blood and hemopoietic system, Congenital disorder, Birth weight ratios, Hyperinsulinemia -- Pregnant women, Hypoxaemia, Pregnancy diabetes mellitus, Umbilical cord blood, Anoxemia, C-Peptide, Fetal Blood, Hyperinsulinism, Infant, Newborn, Diabetes in pregnancy -- Risk factors, In utero fetal hypoxaemia, Macrosomia, Oxygen transport in blood
Citation
MacFarlane, C.M., Tsakalakos, N. 1985. Evidence of hyperinsulinaemia and hypoxaemia in the cord blood of neonates born to mothers with gestational diabetes. South African Medical Journal, vol. 67, January 19 : pp. 82-84