Diversity and antimicrobial activity of culturable fungal endophytes in Solanum mauritianum

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dc.contributor.authorPelo, Sharonen_ZA
dc.contributor.authorMavumengwana, Vuyoen_ZA
dc.contributor.authorGreen, Ezekielen_ZA
dc.date.accessioned2022-09-06T11:58:34Zen_ZA
dc.date.available2022-09-06T11:58:34Zen_ZA
dc.date.issued2020-01en_ZA
dc.descriptionCITATION: Pelo, S., Mavumengwana, V. & Green, E. 2020. Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum. International Journal of Environmental Research and Public Health, 17(2). doi:10.3390/ijerph17020439en_ZA
dc.descriptionThe original publication is available at https://www.mdpi.com/journal/ijerphen_ZA
dc.description.abstractPlant endophytes are microbial sources of bioactive secondary metabolites, which mimic the natural compounds chemistry of their respective host plants in a similar manner. This study explored the isolation and identification of fungal endophytes, and investigated the antibacterial and antimycobacterial activity of their crude extracts. Fungal endophytes were isolated from Solanum mauritianum, identified using morphological traits and internal transcribed spacer ribosomal-deoxyribonucleic acid (ITS-rDNA) sequence analysis. Eight fungal endophytes were identified as Aureobasidium pullulans, Paracamarosporium leucadendri, Cladosporium sp., Collectotrichum boninense, Fusarium sp., Hyalodendriella sp., and Talaromyces sp., while Penicillium chrysogenum was isolated from the leaves and unripe fruits. Good activity was observed for the crude extracts of Paracamarosporium leucadendri inhibiting Mycobacterium bovis, Klebsiella pneumoniae, and Pseudomonas aeruginosa at 6 µg/mL. Crude extracts of Fusarium sp., showed activity at 9 μg/mL against M. bovis, M. smegmatis and K. pneumonia. In general, the crude extracts showed great activity against Gram-negative and Gram-positive bacteria and novel results for two mycobacteria species M. bovis and M. smegmatis. The results provide evidence of diverse fungal endophytes isolated from Solanum mauritianum, and evidence that fungal endophytes are a good source of bioactive compounds with pharmaceutical potential, particularly against Mycobacterium tuberculosis.en_ZA
dc.description.urihttps://www.mdpi.com/1660-4601/17/2/439en_ZA
dc.description.versionPublishers versionen_ZA
dc.format.extent11 pagesen_ZA
dc.identifier.citationPelo, S., Mavumengwana, V. & Green, E. 2020. Diversity and Antimicrobial Activity of Culturable Fungal Endophytes in Solanum mauritianum. International Journal of Environmental Research and Public Health, 17(2). doi:10.3390/ijerph17020439en_ZA
dc.identifier.issn1660-4601 (online)en_ZA
dc.identifier.issn1661-7827 (print)en_ZA
dc.identifier.otherdoi:10.3390/ijerph17020439en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125696en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherMDPIen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectEndophytic fungien_ZA
dc.subjectAnti-infective agentsen_ZA
dc.subjectHost plants -- Morphologyen_ZA
dc.subjectMetabolitesen_ZA
dc.subjectMycobacterium tuberculosisen_ZA
dc.subjectSolanum mauritianumen_ZA
dc.subjectPenicillium chrysogenumen_ZA
dc.titleDiversity and antimicrobial activity of culturable fungal endophytes in Solanum mauritianumen_ZA
dc.typeArticleen_ZA
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