Clinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congo

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dc.contributor.authorNachega, Jean B.en_ZA
dc.contributor.authorIshoso, Daniel Katuashien_ZA
dc.contributor.authorOtokoye, John Otshudiemaen_ZA
dc.contributor.authorHermans, Michel P.en_ZA
dc.contributor.authorMachekano, Rhoderick Nerien_ZA
dc.contributor.authorSam-Agudu, Nadia A.en_ZA
dc.contributor.authorNswe, Christian Bongo-Pasien_ZA
dc.contributor.authorMbala-Kingebeni, Placideen_ZA
dc.contributor.authorMadinga, Joule Ntwanen_ZA
dc.contributor.authorMukendi, Stephaneen_ZA
dc.contributor.authorKoli, Marie Claireen_ZA
dc.contributor.authorNkwembe, Edith N.en_ZA
dc.contributor.authorMbuyi, Gisele M.en_ZA
dc.contributor.authorNsio, Justus M.en_ZA
dc.contributor.authorTshialala, Didier Mukebaen_ZA
dc.contributor.authorPipo, Michel Tshiasumaen_ZA
dc.contributor.authorAhuka-Mundeke, Steveen_ZA
dc.contributor.authorMuyembe-Tamfum, Jean-Jacquesen_ZA
dc.contributor.authorMofenson, Lynneen_ZA
dc.contributor.authorSmith, Geralden_ZA
dc.contributor.authorMills, Edward J.en_ZA
dc.contributor.authorMellors, John W.en_ZA
dc.contributor.authorZumla, Alimuddinen_ZA
dc.contributor.authorLandu, Don Jethro Mavunguen_ZA
dc.contributor.authorKayembe, Jean-Marieen_ZA
dc.date.accessioned2021-02-01T09:53:03Z
dc.date.available2021-02-01T09:53:03Z
dc.date.issued2020
dc.descriptionCITATION: Nachega, J. B. et al. 2020. Clinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congo. American Journal of Tropical Medicine and Hygiene, 103(6):2419–2428, doi:10.4269/ajtmh.20-1240.
dc.descriptionThe original publication is available at https://www.ajtmh.org
dc.description.abstractENGLISH ABSTRACT: Little is known about the clinical features and outcomes of SARS-CoV-2 infection in Africa. We conducted a retrospective cohort study of patients hospitalized for COVID-19 between March 10, 2020 and July 31, 2020 at seven hospitals in Kinshasa, Democratic Republic of the Congo (DRC). Outcomes included clinical improvement within 30 days (primary) and in-hospital mortality (secondary). Of 766 confirmed COVID-19 cases, 500 (65.6%) were male, with a median (interquartile range [IQR]) age of 46 (34–58) years. One hundred ninety-one (25%) patients had severe/critical disease requiring admission in the intensive care unit (ICU). Six hundred twenty patients (80.9%) improved and were discharged within 30 days of admission. Overall in-hospital mortality was 13.2% (95% CI: 10.9–15.8), and almost 50% among those in the ICU. Independent risk factors for death were age < 20 years (adjusted hazard ratio [aHR] = 6.62, 95% CI: 1.85–23.64), 40–59 years (aHR = 4.45, 95% CI: 1.83–10.79), and ³ 60 years (aHR = 13.63, 95% CI: 5.70–32.60) compared with those aged 20–39 years, with obesity (aHR = 2.30, 95% CI: 1.24–4.27), and with chronic kidney disease (aHR = 5.33, 95% CI: 1.85–15.35). In marginal structural model analysis, there was no statistically significant difference in odds of clinical improvement (adjusted odds ratio [aOR] = 1.53, 95% CI: 0.88–2.67, P = 0.132) nor risk of death (aOR = 0.65, 95% CI: 0.35–1.20) when comparing the use of chloroquine/azithromycin versus other treatments. In this DRC study, the high mortality among patients aged < 20 years and with severe/critical disease is of great concern, and requires further research for confirmation and targeted interventions.en_ZA
dc.description.urihttps://www.ajtmh.org/view/journals/tpmd/103/6/article-p2419.xml
dc.description.versionPublisher's version
dc.format.extent10 pagesen_ZA
dc.identifier.citationNachega, J. B. et al. 2020. Clinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congo. American Journal of Tropical Medicine and Hygiene, 103(6):2419–2428, doi:10.4269/ajtmh.20-1240.
dc.identifier.issn1476-1645 (online)
dc.identifier.otherdoi:10.4269/ajtmh.20-1240
dc.identifier.urihttp://hdl.handle.net/10019.1/109485
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society of Tropical Medicine and Hygieneen_ZA
dc.rights.holderAmerican Society of Tropical Medicine and Hygieneen_ZA
dc.subjectCOVID-19 (Disease)en_ZA
dc.subjectCoronavirus infectionsen_ZA
dc.subjectAfricaen_ZA
dc.subjectClinical signsen_ZA
dc.titleClinical characteristics and outcomes of patients hospitalized for COVID-19 in Africa : early insights from the Democratic Republic of the Congoen_ZA
dc.typeArticleen_ZA
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