B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients

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dc.contributor.authorFlepisi, Brian T.en_ZA
dc.contributor.authorBouic, Patricken_ZA
dc.contributor.authorSissolak, Gerharden_ZA
dc.contributor.authorRosenkranz, Bernden_ZA
dc.date.accessioned2020-02-10T09:57:41Z
dc.date.available2020-02-10T09:57:41Z
dc.date.issued2018
dc.descriptionCITATION: Flepisi, B. T., et al. 2018. B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients. Southern African Journal of HIV Medicine, 19(1):a809, doi:10.4102/sajhivmed.v19i1.809.
dc.descriptionThe original publication is available at https://sajhivmed.org.za
dc.description.abstractBackground: Altered immune mechanisms play a critical role in the pathogenesis of non-Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased T-cell turnover and lymph node fibrosis. Objectives: This study aimed to determine the serum levels of circulating B-cell activation markers, and the expression of T-cell activation and regulatory markers in HIV-positive NHL patients. Method: The serum levels of circulating soluble(s) sCD20, sCD23, sCD27, sCD30 and sCD44 molecules, all of which are biomarkers of B-cell activation, were determined by enzyme-linked immunosorbent assays (ELISA), while biomarkers of T-cell activation (CD8+CD38+) and regulation (FoxP3) were determined by flow cytometry in 141 subjects who were divided into five groups: Combination antiretroviral therapy (ART)-naïve HIV-positive patients; ART-treated HIV-positive patients; HIV-negative NHL patients; HIV-positive NHL patients on ART; and healthy controls. Results: HIV-positive NHL patients had significantly higher serum levels of sCD20, sCD23, sCD30 and sCD44 than HIV-negative NHL patients, while all five biomarkers were significantly elevated in HIV-positive NHL patients when compared with ART-treated HIV-positive patients. HIV-positive NHL patients had higher CD8+CD38+ and lower FoxP3 expression than HIV-negative NHL and ART-treated HIV-positive patients. Conclusion: B-cell activation is increased in HIV-positive NHL patients and is associated with reduced regulatory T-cell populations and increased CD8+ T-cell activation.en_ZA
dc.description.urihttps://sajhivmed.org.za/index.php/HIVMED/article/view/809
dc.description.versionPublisher's version
dc.format.extent7 pages
dc.identifier.citationFlepisi, B. T., et al. 2018. B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients. Southern African Journal of HIV Medicine, 19(1):a809, doi:10.4102/sajhivmed.v19i1.809
dc.identifier.issn2078-6751 (online)
dc.identifier.issn1608-9693 (print)
dc.identifier.otherdoi:10.4102/sajhivmed.v19i1.809
dc.identifier.urihttp://hdl.handle.net/10019.1/107460
dc.language.isoen_ZAen_ZA
dc.publisherMedpharm Publications
dc.rights.holderAuthors retain copyright
dc.subjectHIV-positive persons -- South Africaen_ZA
dc.subjectHIV (Viruses) -- Analysisen_ZA
dc.subjectB cells -- Mechanism of actionen_ZA
dc.subjectT cells -- Mechanism of actionen_ZA
dc.subjectCell interaction -- Immunologyen_ZA
dc.subjectLymphomas -- Patients -- South Africaen_ZA
dc.subjectNon-Hodgkin’s lymphoma -- Infectionsen_ZA
dc.titleB-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patientsen_ZA
dc.typeArticleen_ZA
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