Clinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africa

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dc.contributor.advisorBekker, Adrieen_ZA
dc.contributor.advisorDramowski, Angelaen_ZA
dc.contributor.authorAryao, Ruthen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health.en_ZA
dc.date.accessioned2020-11-16T12:14:54Zen_ZA
dc.date.accessioned2021-01-31T18:20:25Zen_ZA
dc.date.available2020-11-16T12:14:54Zen_ZA
dc.date.available2021-01-31T18:20:25Zen_ZA
dc.date.issued2020-12en_ZA
dc.descriptionThesis (MMed)--Stellenbosch University, 2020.en_ZA
dc.description.abstractENGLISH ABSTRACT: Introduction: Limited data are available regarding the presentation, clinical course and outcome of infants (<12 months of age) treated for drug-susceptible tuberculosis. Methods: Infants with tuberculosis admitted at Tygerberg, Khayelitsha District and Brooklyn Chest Hospitals (March 2014-March 2015) were prospectively enrolled with follow-up evaluations at 3- and 6-months post-treatment initiation. Results: Among 39 infants diagnosed with tuberculosis, 21 (54%) had known contact with an adult tuberculosis source case. The median age of infants at diagnosis was 6 months (IQR 3-7) and median weight 5.2 kg (IQR 3.2–10.2). Twenty-two of 39 (56%) were exposed to HIV of whom 5 were HIV infected. Growth faltering (25; 68%) and persistent cough (13; 33%) were frequent presenting symptoms. Most infants were diagnosed with intrathoracic tuberculosis (37/39; 95%) while 5% had disseminated tuberculosis and (14/39; 36%) had culture-confirmed tuberculosis. Alveolar opacification (22; 56%), mediastinal lymphadenopathy (13; 33%) and large airway obstruction (8; 20%) were common chest radiography findings. Tuberculosis treatment outcomes were favourable in 33/39 (85%) infants, but with additional intervention 37 (95%) completed treatment. Conclusions: Intrathoracic tuberculosis was the predominant disease type and one-third of the cohort had culture-confirmed tuberculosis. More than half on the infants were born to a mother with HIV. An adult tuberculosis source case was identifiable in half of the cases. Additional interventions improved favourable treatment outcomes.en_ZA
dc.description.abstract"Geen opsomming beskikbaar"af_ZA
dc.description.versionMastersen_ZA
dc.embargo.terms2021-12en_ZA
dc.format.extent14 pagesen_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/109051
dc.language.isoen_ZAen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subjectTuberculosis in childrenen_ZA
dc.subjectTuberculin testen_ZA
dc.subjectTuberculosis source caseen_ZA
dc.subjectPaediatric tuberculosisen_ZA
dc.subjectUCTDen_ZA
dc.titleClinical presentation and treatment outcomes of infants with tuberculosis in Cape Town, South Africaen_ZA
dc.typeThesisen_ZA
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