Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation

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mabank_synthesis_2019.pdf(1.06 MB)
Date
2019
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Journal ISSN
Volume Title
Publisher
ARKAT USA
Abstract
ENGLISH ABSTRACT: 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.
Description
CITATION: Mabank, T., et al. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation. ARKIVOC, iv:245-279, doi:10.24820/ark.5550190.p010.962.
The original publication is available at https://www.arkat-usa.org/arkivoc-journal
Keywords
6-Hydroxytetrahydroisoquinolines, Estrogen receptor modulators, Selective, Urea industry, Thiourea, Sulfonamides
Citation
Mabank, T., et al. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation. ARKIVOC, iv:245-279, doi:10.24820/ark.5550190.p010.962
URI
http://hdl.handle.net/10019.1/123417
Collections
Research Articles (Molecular Biology and Human Genetics)