Fas mediated(CD95L) periferal T-cell Apotosis marker in monitoring HIV-1 disease progression in adults in Yaoundé, Cameroon

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dc.contributor.authorIkomey, George Mondindeen_ZA
dc.contributor.authorJulius, Atashilien_ZA
dc.contributor.authorJacobs, Graeme Brendonen_ZA
dc.contributor.authorMesembe, Martha Tongoen_ZA
dc.contributor.authorEyoh, Agnesen_ZA
dc.contributor.authorLyonga, Emiliaen_ZA
dc.contributor.authorClaire, Okomo Assoumou Marieen_ZA
dc.contributor.otherPathology: Medical Virologyen_ZA
dc.date.accessioned2016-07-11T11:01:51Z
dc.date.available2016-07-11T11:01:51Z
dc.date.issued2016-03-22
dc.descriptionCITATION: Ikomey, G. M. et al. 2016. Fas mediated(CD95L) periferal T-cell Apotosis marker in monitoring HIV-1 disease progression in adults in Yaoundé, Cameroon. International Journal of Immunology, 4(1): 1-5, doi:10.11648/j.iji.20160401.11.en_ZA
dc.descriptionThe original publication is available at http://www.sciencepublishinggroup.com/j/ijien_ZA
dc.description.abstractsFas (CD95) / FasL are hallmarks of apoptosis involvement in pathogenesis of HIV. We assess changes in soluble Fas /FasL, CD4 % and HIV-1 viral load in patients prior to the initiation of antiretroviral therapy (ART) and 6 months thereafter. A prospective longitudinal study on sixty consented HIV-1 positive adults. sFas and sFasL levels were measured by ELISA. CD4 cell counts and HIV-1 viralloads were measured using standard methods. Samples were analysed according to the manufacturers’ guidelines.There was a significant positive correlation between HIV-1 viral load and FasL at six months (M6) on treatment [r = +0.49, (0.03)]. There were no correlation between sFas/FasL and CD4 cell counts [ r = -33 (0.16), -31 (0.17) - 23 (0.03) respectively]. The significant correlation between sFasL and HIV-1 viral load at six months of ART suggests that sFasL could be a signal biomarker for HIV-1 disease progression. We have shown in this study that high levels of sFasL depict high HIV-1 viral loads and advance state of the HIV disease. These biomarker should be investigated further in other settings.en_ZA
dc.description.urihttp://www.sciencepublishinggroup.com/home/indexen_ZA
dc.description.urihttp://article.sciencepublishinggroup.com/html/10.11648.j.iji.20160401.11.html
dc.description.versionPublisher's versionen_ZA
dc.format.extent5 pages
dc.identifier.citationIkomey, G. M. et al. 2016. Fas mediated(CD95L) periferal T-cell Apotosis marker in monitoring HIV-1 disease progression in adults in Yaoundé, Cameroon. International Journal of Immunology, 4(1): 1-5, doi:10.11648/j.iji.20160401.11.en_ZA
dc.identifier.issn2329-1753 (online)
dc.identifier.issn2329-177X (print)
dc.identifier.otherdoi:10.11648/j.iji.20160401.11
dc.identifier.urihttp://hdl.handle.net/10019.1/99123
dc.language.isoen_ZAen_ZA
dc.publisherScience Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV infections -- Cameroon -- Yaoundéen_ZA
dc.titleFas mediated(CD95L) periferal T-cell Apotosis marker in monitoring HIV-1 disease progression in adults in Yaoundé, Cameroonen_ZA
dc.typeArticleen_ZA
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