In vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells

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dc.contributor.authorMagcwebeba, Tandeka U.en_ZA
dc.contributor.authorSwart, Pieteren_ZA
dc.contributor.authorSwanevelder, Sonjaen_ZA
dc.contributor.authorJoubert, Elizabethen_ZA
dc.contributor.authorGelderblom, Wentzel C. A.en_ZA
dc.date.accessioned2017-07-19T07:21:30Z
dc.date.available2017-07-19T07:21:30Z
dc.date.issued2016-11-25
dc.descriptionCITATION: Magcwebeba, T. U. et al. 2016. In vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells. Molecules, 21(12):1622, doi:10.3390/molecules21121622.
dc.descriptionThe original publication is available at http://www.mdpi.com/journal/molecules
dc.description.abstractThe chemopreventive properties of the herbal teas rooibos (Aspalathus linearis) and honeybush (Cyclopia spp.) have been demonstrated on mouse skin in vivo but the underlying mechanisms are not clear. The aim of the current study was to determine the anti-proliferative and pro-apoptotic activity of methanol and aqueous extracts of rooibos and two Cyclopia species in different skin cells, using green tea (Camellia sinensis) as a benchmark. Extracts were also characterised for their major individual polyphenols by high performance liquid chromatography and spectroscopically for the total polyphenol (TP) groups. The methanol extract of rooibos, containing higher levels of polyphenols than its aqueous extract, displayed similar activity to green tea as it selectively targeted premalignant cells by inhibiting cell proliferation at lower concentrations whilst inducing apoptosis via membrane depolarisation at higher concentrations. Specific roles of the major rooibos dihydrochalcones and flavanol/proanthocyanidin-type (FLAVA) compounds are likely to be involved. The aqueous extracts of the Cyclopia species were more active against cell proliferation and at inducing apoptosis which was associated with a higher FLAVA content and a reduced TP/FLAVA ratio. In contrast, their methanol extracts exhibited a cytoprotective effect against apoptosis which was related to their monomeric xanthone and flavanone content. The underlying chemopreventive properties of green tea and the herbal teas appear to be associated with diverse and complex monomeric/polymeric polyphenolic cell interactions.en_ZA
dc.description.urihttp://www.mdpi.com/1420-3049/21/12/1622
dc.description.versionPublisher's version
dc.format.extent18 pages
dc.identifier.citationMagcwebeba, T. U. et al. 2016. In vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cells. Molecules, 21(12):1622, doi:10.3390/molecules21121622.
dc.identifier.issn1420-3049 (online)
dc.identifier.otherdoi:10.3390/molecules21121622
dc.identifier.urihttp://hdl.handle.net/10019.1/101991
dc.language.isoen_ZAen_ZA
dc.publisherMDPI
dc.rights.holderAuthors retain copyright
dc.subjectHerbal teaen_ZA
dc.subjectAspalathus linearisen_ZA
dc.subjectRooibos tea -- Therapeutic useen_ZA
dc.subjectHoneybush tea -- Therapeutic useen_ZA
dc.subjectSkin -- Canceren_ZA
dc.titleIn vitro chemopreventive properties of green tea, rooibos and honeybush extracts in skin cellsen_ZA
dc.typeArticleen_ZA
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