TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda

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dc.contributor.authorKalungi, Allanen_ZA
dc.contributor.authorKinyanda, Eugeneen_ZA
dc.contributor.authorWomersley, Jacqueline S.
dc.contributor.authorJoloba, Moses L.
dc.contributor.authorSsembajjwe, Wilberen_ZA
dc.contributor.authorNsubuga, Rebecca N.en_ZA
dc.contributor.authorKaleebu, Pontianoen_ZA
dc.contributor.authorLevin, Jonathanen_ZA
dc.contributor.authorKidd, Martinen_ZA
dc.contributor.authorSeedat, Sorayaen_ZA
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.date.accessioned2021-04-29T10:24:09Z
dc.date.available2021-04-29T10:24:09Z
dc.date.issued2021-01-06
dc.date.updated2021-01-10T04:16:58Z
dc.descriptionCITATION: Kalungi, A., et al. 2021. TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda. BMC Medical Genomics, 14:15, doi:10.1186/s12920-020-00857-z.
dc.descriptionThe original publication is available at https://bmcmedgenomics.biomedcentral.com
dc.description.abstractBackground: Internalizing mental disorders (IMDs) (depression, anxiety and post-traumatic stress disorder) have been associated with accelerated telomere length (TL) attrition; however, this association has not been investigated in the context of genetic variation that has been found to influence TL. We have previously reported an association between IMDs and accelerated TL attrition among Ugandan HIV+ children and adolescents. This study investigated the moderating effects of selected single nucleotide polymorphisms in the telomerase reverse transcriptase gene (TERT) (rs2736100, rs7726159, rs10069690 and rs2853669) and the telomerase RNA component gene (TERC) (rs12696304, rs16847897 and rs10936599) on the association between IMDs and TL, among Ugandan HIV+ children (aged 5–11 years) and adolescents (aged 12–17 years). Results: We found no significant interaction between IMDs as a group and any of the selected SNPs on TL at baseline. We observed significant interactions of IMDs with TERT rs2736100 (p = 0.007) and TERC rs16847897 (p = 0.012), respectively, on TL at 12 months. Conclusions: TERT rs2736100 and TERC rs16847897 moderate the association between IMDs and TL among Ugandan HIV+ children and adolescents at 12 months. Understanding the nature of this association may shed light on the pathophysiological mechanisms underlying advanced cellular aging in IMDs.en_ZA
dc.description.urihttps://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-020-00857-z
dc.description.versionPublisher's version
dc.format.extent10 pages
dc.identifier.citationKalungi, A., et al. 2021. TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda. BMC Medical Genomics, 14:15, doi:10.1186/s12920-020-00857-z
dc.identifier.issn1755-8794 (online)
dc.identifier.otherdoi:10.1186/s12920-020-00857-z
dc.identifier.urihttp://hdl.handle.net/10019.1/110382
dc.language.isoen_ZAen_ZA
dc.publisherBMC (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectInternalizing mental disordersen_ZA
dc.subjectDepression in childrenen_ZA
dc.subjectHIV-positive children -- Mental health -- Ugandaen_ZA
dc.subjectTelomere attritionen_ZA
dc.subjectGenomicsen_ZA
dc.subjectCells -- Agingen_ZA
dc.titleTERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Ugandaen_ZA
dc.typeArticleen_ZA
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