International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

Simple item page
dc.contributor.authorNievergelt, Caroline M.en_ZA
dc.contributor.authorMaihofer, Adam X.en_ZA
dc.contributor.authorKlengel, Torstenen_ZA
dc.contributor.authorAtkinson, Elizabeth G.en_ZA
dc.contributor.authorChen, Chia-Yenen_ZA
dc.contributor.authorChoi, Karmel W.en_ZA
dc.contributor.authorColeman, Jonathan R. I.en_ZA
dc.contributor.authorDalvie, Shareefaen_ZA
dc.contributor.authorDuncan, Laramie E.en_ZA
dc.contributor.authorGelernter, Joelen_ZA
dc.contributor.authorLevey, Daniel F.en_ZA
dc.contributor.authorLogue, Mark W.en_ZA
dc.contributor.authorPolimanti, Renatoen_ZA
dc.contributor.authorProvost, Allison C.en_ZA
dc.contributor.authorRatanatharathorn, Andrewen_ZA
dc.contributor.authorStein, Murray B.en_ZA
dc.contributor.authorTorres, Katyen_ZA
dc.contributor.authorAiello, Allison E.en_ZA
dc.contributor.authorAlmli, Lynn M.en_ZA
dc.contributor.authorAmstadter, Ananda B.en_ZA
dc.contributor.authorAndersen, Soren B.en_ZA
dc.contributor.authorAndreassen, Ole A.en_ZA
dc.contributor.authorArbisi, Paul A.en_ZA
dc.contributor.authorAshley-Koch, Allison E.en_ZA
dc.contributor.authorAustin, S. Brynen_ZA
dc.contributor.authorAvdibegovic, Esminaen_ZA
dc.contributor.authorBabic, Draganen_ZA
dc.contributor.authorBækvad-Hansen, Marieen_ZA
dc.contributor.authorBaker, Dewleen G.en_ZA
dc.contributor.authorBeckham, Jean C.en_ZA
dc.contributor.authorBierut, Laura J.en_ZA
dc.contributor.authorBisson, Jonathan I.en_ZA
dc.contributor.authorBoks, Marco P.en_ZA
dc.contributor.authorBolger, Elizabeth A.en_ZA
dc.contributor.authorBorglum, Anders D.en_ZA
dc.contributor.authorBradley, Bekhen_ZA
dc.contributor.authorBrashear, Meganen_ZA
dc.contributor.authorBreen, Geromeen_ZA
dc.contributor.authorBryant, Richard A.en_ZA
dc.contributor.authorBustamante, Angela C.en_ZA
dc.contributor.authorBybjerg-Grauholm, Jonasen_ZA
dc.contributor.authorCalabrese, Joseph R.en_ZA
dc.contributor.authorCaldas-de-Almeida, Jose M.en_ZA
dc.contributor.authorDale, Anders M.en_ZA
dc.contributor.authorDaly, Mark J.en_ZA
dc.contributor.authorDaskalakis, Nikolaos P.en_ZA
dc.contributor.authorDeckert, Jurgenen_ZA
dc.contributor.authorDelahanty, Douglas L.en_ZA
dc.contributor.authorDennis, Michelle F.en_ZA
dc.contributor.authorDisner, Seth G.en_ZA
dc.contributor.authorDomschke, Katharinaen_ZA
dc.contributor.authorDzubur-Kulenovic, Almaen_ZA
dc.contributor.authorErbes, Christopher R.en_ZA
dc.contributor.authorEvans, Alexandraen_ZA
dc.contributor.authorFarrer, Lindsay A.en_ZA
dc.contributor.authorFeeny, Norah C.en_ZA
dc.contributor.authorFlory, Janine D.en_ZA
dc.contributor.authorForbes, Daviden_ZA
dc.contributor.authorFranz, Carol E.en_ZA
dc.contributor.authorGalea, Sandroen_ZA
dc.contributor.authorGarrett, Melanie E.en_ZA
dc.contributor.authorGelaye, Bizuen_ZA
dc.contributor.authorGeuze, Elberten_ZA
dc.contributor.authorGillespie, Charlesen_ZA
dc.contributor.authorUka, Aferdita Gocien_ZA
dc.contributor.authorGoci, Aferditaen_ZA
dc.contributor.authorGuffanti, Guiaen_ZA
dc.contributor.authorHammamieh, Rashaen_ZA
dc.contributor.authorHarnal, Supriyaen_ZA
dc.contributor.authorHauser, Michael A.en_ZA
dc.contributor.authorHeath, Andrew C.en_ZA
dc.contributor.authorHemmings, Sian M. J.en_ZA
dc.contributor.authorHougaard, David Michaelen_ZA
dc.contributor.authorJakovljevic, Miroen_ZA
dc.contributor.authorJett, Martien_ZA
dc.contributor.authorJohnson, Eric Ottoen_ZA
dc.contributor.authorJones, Ianen_ZA
dc.contributor.authorJovanovic, Tanjaen_ZA
dc.contributor.authorQin, Xue-Junen_ZA
dc.contributor.authorJunglen, Angela G.en_ZA
dc.contributor.authorKarstoft, Karen-Ingeen_ZA
dc.contributor.authorKaufman, Milissa L.en_ZA
dc.contributor.authorKessler, Ronald C.en_ZA
dc.contributor.authorKhan, Alaptaginen_ZA
dc.contributor.authorKimbre, Nathan A.en_ZA
dc.contributor.authorKing, Anthony P.en_ZA
dc.contributor.authorKoen, Nastassjaen_ZA
dc.contributor.authorKranzler, Henry R.en_ZA
dc.contributor.authorKremen, William S.en_ZA
dc.contributor.authorLawford, Bruce R.en_ZA
dc.contributor.authorLebois, Lauren A. M.en_ZA
dc.contributor.authorLewis, Catrin E.en_ZA
dc.contributor.authorLinnstaedt, Sarah D.en_ZA
dc.contributor.authorLori, Adrianaen_ZA
dc.contributor.authorLugonja, Bozoen_ZA
dc.contributor.authorLuykx, Jurjen J.en_ZA
dc.contributor.authorLyons, Michael J.en_ZA
dc.contributor.authorMaples-Keller, Jessicaen_ZA
dc.contributor.authorMarmar, Charlesen_ZA
dc.contributor.authorMartin, Alicia R.en_ZA
dc.contributor.authorMaurer, Douglasen_ZA
dc.contributor.authorMavissakalian, Matig R.en_ZA
dc.contributor.authorMcFarlane, Alexanderen_ZA
dc.contributor.authorMcGlinchey, Regina E.en_ZA
dc.contributor.authorMcLaughlin, Katie A.en_ZA
dc.contributor.authorMcLean, Samuel A.en_ZA
dc.contributor.authorMcLeay, Sarahen_ZA
dc.contributor.authorMehta, Divyaen_ZA
dc.contributor.authorMilberg, William P.en_ZA
dc.contributor.authorMiller, Mark W.en_ZA
dc.contributor.authorMorey, Rajendra A.en_ZA
dc.contributor.authorMorris, Charles Phillipen_ZA
dc.contributor.authorMors, Oleen_ZA
dc.contributor.authorMortensen, Preben B.en_ZA
dc.contributor.authorNeale, Benjamin M.en_ZA
dc.contributor.authorNelson, Elliot C.en_ZA
dc.contributor.authorNordentoft, Mereteen_ZA
dc.contributor.authorNorman, Sonya B.en_ZA
dc.contributor.authorO'Donnell, Meaghanen_ZA
dc.contributor.authorOrcutt, Holly K.en_ZA
dc.contributor.authorPanizzon, Matthew S.en_ZA
dc.contributor.authorPeters, Edward S.en_ZA
dc.contributor.authorPeterson, Alan L.en_ZA
dc.contributor.authorPeverill, Matthewen_ZA
dc.contributor.authorPietrzak, Robert H.en_ZA
dc.contributor.authorPolusny, Melissa A.en_ZA
dc.contributor.authorRice, John P.en_ZA
dc.contributor.authorRipke, Stephanen_ZA
dc.contributor.authorRisbrough, Victoria B.en_ZA
dc.contributor.authorRoberts, Andrea L.en_ZA
dc.contributor.authorRothbaum, Alex O.en_ZA
dc.contributor.authorRothbaum, Barbara O.en_ZA
dc.contributor.authorRoy-Byrne, Peteren_ZA
dc.contributor.authorRuggiero, Kenen_ZA
dc.contributor.authorRung, Arianeen_ZA
dc.contributor.authorRutten, Bart P. F.en_ZA
dc.contributor.authorSaccone, Nancy L.en_ZA
dc.contributor.authorSanchez, Sixto E.en_ZA
dc.contributor.authorSchijven, Dicken_ZA
dc.contributor.authorSeedat, Soraya, 1966-en_ZA
dc.contributor.authorSeligowski, Antonia V.en_ZA
dc.contributor.authorSeng, Julia S.en_ZA
dc.contributor.authorSheerin, Christina M.en_ZA
dc.contributor.authorSmith, Alicia K.en_ZA
dc.contributor.authorSmoller, Jordan W.en_ZA
dc.contributor.authorSponheim, Scott R.en_ZA
dc.contributor.authorStein, Dan J.en_ZA
dc.contributor.authorStevens, Jennifer S.en_ZA
dc.contributor.authorSumner, Jennifer A.en_ZA
dc.contributor.authorTeicher, Martin H.en_ZA
dc.contributor.authorThompson, Wesley K.en_ZA
dc.contributor.authorTrapido, Edwarden_ZA
dc.contributor.authorUddin, Monicaen_ZA
dc.contributor.authorUrsano, Robert J.en_ZA
dc.contributor.authorVan Den Heuvel, Leigh Luellaen_ZA
dc.contributor.authorVan Hooff, Mirandaen_ZA
dc.contributor.authorVermetten, Ericen_ZA
dc.contributor.authorVinkers, Christiaan H.en_ZA
dc.contributor.authorVoisey, Joanneen_ZA
dc.contributor.authorWang, Yunpengen_ZA
dc.contributor.authorWang, Zhewuen_ZA
dc.contributor.authorWerge, Thomasen_ZA
dc.contributor.authorWilliams, Michelle A.en_ZA
dc.contributor.authorWilliamson, Douglas E.en_ZA
dc.contributor.authorWinternitz, Sherryen_ZA
dc.contributor.authorWolf, Christianeen_ZA
dc.contributor.authorWolf, Erika J.en_ZA
dc.contributor.authorWolff, Jonathan D.en_ZA
dc.contributor.authorYehuda, Rachelen_ZA
dc.contributor.authorYoung, Ross McDen_ZA
dc.contributor.authorYoung, Keith A.en_ZA
dc.contributor.authorZhao, Hongyuen_ZA
dc.contributor.authorZoellner, Lori A.en_ZA
dc.contributor.authorLiberzon, Israelen_ZA
dc.contributor.authorRessler, Kerry J.en_ZA
dc.contributor.authorHaas, Magalien_ZA
dc.contributor.authorKoenen, Karestan C.en_ZA
dc.date.accessioned2021-10-06T12:27:03Z
dc.date.available2021-10-06T12:27:03Z
dc.date.issued2019
dc.descriptionCITATION: Nievergelt, C. M., et al . 2019. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications, 10:4558, doi:10.1038/s41467-019-12576-w.
dc.descriptionThe original publication is available at https://www.nature.com
dc.description.abstractThe risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations.en_ZA
dc.description.urihttps://www.nature.com/articles/s41467-019-12576-w
dc.description.versionPublisher's version
dc.format.extent16 pages ; illustrations
dc.identifier.citationNievergelt, C. M., et al . 2019. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci. Nature Communications, 10:4558, doi:10.1038/s41467-019-12576-w
dc.identifier.issn2041-1723 (online)
dc.identifier.otherdoi:10.1038/s41467-019-12576-w
dc.identifier.urihttp://hdl.handle.net/10019.1/123141
dc.language.isoen_ZAen_ZA
dc.publisherNature Research (part of Springer Nature)
dc.rights.holderAuthors retain copyright
dc.subjectPost-traumatic stress disorder -- Genetic aspects -- Risk factorsen_ZA
dc.subjectPost-traumatic stress disorder -- Sex differences -- Risk factorsen_ZA
dc.subjectMeta-analysisen_ZA
dc.titleInternational meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk locien_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
nievergelt_international_2019.pdf
Size:
2.98 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Psychiatry)