Severe acute respiratory infection with influenza A (H1N1) during pregnancy
Date
2009-10
Authors
Langenegger, Eduard
Coetzee, Andre
Jacobs, Samier
Le Roux, Alrisah
Theron, Gerhard
Journal Title
Journal ISSN
Volume Title
Publisher
Health and Medical Publishing Group (HMPG)
Abstract
ABSTRACT FROM JOURNAL: Pregnant women are at high risk of severe acute
respiratory infection if infected with the influenza A (H1N1)
virus. On 14 August 2009 the first complicated H1N1 obstetric
patient was admitted to the obstetric critical care unit (OCCU)
at Tygerberg Hospital with respiratory distress. The clinical
picture was that of bronchopneumonia, and she tested positive
for H1N1. Subsequent pregnant patients admitted to the OCCU
with respiratory compromise or flu symptoms were screened
for the virus.
Eleven days later 13 cases were confirmed. Five patients
had acute lung injury and required ventilation and inotropic
support. Three of the patients with acute lung injury
subsequently died. Three patients required continuous positive
airway pressure (CPAP) support only, with no inotropics
needed. The remaining 5 patients presented early, received
oseltamivir within 48 hours and did not require critical care
admission.
All the patients admitted to the OCCU and the medical
intensive care unit (ICU) initially presented with flu symptoms,
respiratory distress and changes on the chest radiograph
indicating an active diffuse pulmonary parenchymal process.
Six patients underwent uncomplicated caesarean sections for
fetal distress after they were stabilised. Maternal and neonatal
outcomes varied. The key factor appears to be early clinical
diagnosis and oseltamivir within 48 hours of the onset of
symptoms. The demographic data and maternal and fetal
outcomes are set out in Table I.
Description
The original publication is available at http://www.samj.org.za
Keywords
Acute respiratory infection, Influenza A, H1N1, Pregnancy, Critical care management
Citation
Langenegger, E et.al 2009, Severe acute respiratory infection with influenza A (H1N1) during pregnancy, South African Medical Journal vol. 99(10) 713-716, http://www.samj.org.za/index.php/samj