Outcomes of extremely low-birthweight neonates at a tertiary hospital in the Western Cape, South Africa : a retrospective cohort study

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dc.contributor.authorMugyenzi, Grace Musiimeen_ZA
dc.contributor.authorLloyd, L. G.en_ZA
dc.contributor.authorMcCaul, M.en_ZA
dc.contributor.authorVan Zyl, N.en_ZA
dc.contributor.authorHolgate, S. L.en_ZA
dc.date.accessioned2022-10-14T09:44:36Zen_ZA
dc.date.available2022-10-14T09:44:36Zen_ZA
dc.date.issued2021-10en_ZA
dc.descriptionCITATION: Musiime, G. M. et al. 2021. Outcomes of extremely low-birthweight neonates at a tertiary hospital in the Western Cape, South Africa : a retrospective cohort study. South African Journal of Child Health, 15(3):170-175, doi:10.7196/SAJCH.2021.v15i3.01799.en_ZA
dc.descriptionThe original publication is available at http://www.sajch.org.zaen_ZA
dc.description.abstractBackground. Neonates of extremely low birthweight (ELBW; <1 000 g) have the highest neonatal mortality in South Africa (SA). Objective. To describe the morbidity and mortality of ELBW neonates treated at a tertiary hospital in SA. Methods. This was a retrospective cohort study including all live-born ELBW neonates treated at Tygerberg Hospital between 1 January and 31 December 2016. Data were extrapolated from a prospectively collected neonatal database and patient records. Multiple logistic regression and survival analysis were performed to identify risk factors of mortality. Results. The sample included 256 neonates. The following morbidities were recorded: respiratory distress syndrome (83.2%); bronchopulmonary dysplasia (8.2%); intraventricular haemorrhage (34.5%); periventricular leukomalacia (0.6%); necrotising enterocolitis (10.5%); and retinopathy of prematurity (31.2%). The survival-to-discharge rate was 63.3%. Cause of death was documented as extreme prematurity in 41% of the inpatient deaths. Birthweight was a significant predictor of mortality (hazard ratio 0.99; 95% confidence interval 0.992 - 0.999). Of the 162 neonates who survived until discharge, 11 died following discharge. Conclusion. Morbidity and mortality rates remain high among ELBW neonates. To improve survival, resources need to be allocated to neonatal resuscitation, surfactant therapy and increasing availability of intensive-care beds.en_ZA
dc.description.urihttp://www.sajch.org.za/index.php/SAJCH/article/view/1632en_ZA
dc.description.versionPublisher's versionen_ZA
dc.format.extent6 pagesen_ZA
dc.identifier.citationMusiime, G. M. et al. 2021. Outcomes of extremely low-birthweight neonates at a tertiary hospital in the Western Cape, South Africa : a retrospective cohort study. South African Journal of Child Health, 15(3):170-175, doi:10.7196/SAJCH.2021.v15i3.01799.en_ZA
dc.identifier.issn1999-7671 (online)en_ZA
dc.identifier.issn1994-3032 (print)en_ZA
dc.identifier.otherdoi:10.7196/SAJCH.2021.v15i3.01799en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125765en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherHealth & Medical Publishing Groupen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectBirth weight, Lowen_ZA
dc.subjectNewborn infants -- Mortalityen_ZA
dc.subjectAcademic medical centersen_ZA
dc.subjectRespiratory distress syndromeen_ZA
dc.subjectNewborn infants -- Deathen_ZA
dc.titleOutcomes of extremely low-birthweight neonates at a tertiary hospital in the Western Cape, South Africa : a retrospective cohort studyen_ZA
dc.typeArticleen_ZA
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