Trace element concentration changes in brain tumors : a review

Simple item page
dc.contributor.authorCilliers, Karenen_ZA
dc.contributor.authorMuller, Christo J. F.en_ZA
dc.contributor.authorPage, Benedict J.en_ZA
dc.date.accessioned2022-05-23T08:23:16Zen_ZA
dc.date.available2022-05-23T08:23:16Zen_ZA
dc.date.issued2020-05en_ZA
dc.descriptionCITATION: Cilliers, K. et al. 2020. Trace element concentration changes in brain tumors: a review. The Anatomical Record, 303:1293-1299. doi:10.1002/ar.24254en_ZA
dc.descriptionThe original publication is available at https://anatomypubs.onlinelibrary.wiley.com/journal/19328494en_ZA
dc.description.abstractTrace elements have been implicated in cancer, since the levels differ between cancerous and noncancerous tissue, different cancer types, and different malignancy grades. However, few studies have been conducted on trace element concentrations in brain tumors. Thus, this study aims to review the available literature on trace element changes related to brain tumors, and to identify gaps in the literature. A literature search was done on Google Scholar and PubMed from their start date to January 2018, using terms related to trace element concentration and brain tumors. All brain tumor types were included, and articles could be published in any year. From this search, only 11 articles on this topic could be found. Tumors had significantly higher concentrations of arsenic, thorium, lanthanum, lutetium, cerium, and gadolinium compared to control brain samples. Compared to adjacent tissue, tumor tissue indicated increased magnesium, decreased copper, and contradicting results for zinc. Furthermore, the higher the malignancy grade, the lower the calcium, cadmium, iron, phosphorus and sulfur concentration, and the higher the mercury, manganese, lead, and zinc concentrations. In conclusion, altered trace element levels differ amongst different tumor types, as well as malignancy grades. Consequently, it is impossible to compare data from these studies, and available data are still considerably inconclusive. Ideally, future studies should have a sufficient samples size, compare different tumor types, and compare tumors with adjacent healthy tissue as well as with samples from unaffected matched brains. Anat Rec, 303:1293-1299, 2020. © 2019 American Association for Anatomy.en_ZA
dc.description.urihttps://anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/ar.24254en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent7 pagesen_ZA
dc.identifier.citationCilliers, K. et al. 2020. Trace element concentration changes in brain tumors: a review. The Anatomical Record, 303:1293-1299. doi:10.1002/ar.24254en_ZA
dc.identifier.issn1932-8494 (online)en_ZA
dc.identifier.otherdoi:10.1002/ar.24254en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/125229en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Association for Anatomyen_ZA
dc.rights.holderAmerican Association for Anatomyen_ZA
dc.subjectGlioblastoma multiformeen_ZA
dc.subjectMalignant tumorsen_ZA
dc.subjectTrace elementsen_ZA
dc.subjectCentral nervous system -- Canceren_ZA
dc.titleTrace element concentration changes in brain tumors : a reviewen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
cilliers_trace_2019.pdf
Size:
109.51 KB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Anatomy and Histology)