A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation

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dc.contributor.authorViolari, Avyen_ZA
dc.contributor.authorCotton, Mark F.en_ZA
dc.contributor.authorKuhn, Louiseen_ZA
dc.contributor.authorSchramm, Diana B.en_ZA
dc.contributor.authorPaximadis, Mariaen_ZA
dc.contributor.authorLoubser, Shayneen_ZA
dc.contributor.authorShalekoff, Sharonen_ZA
dc.contributor.authorDa Costa Dias, Biancaen_ZA
dc.contributor.authorOtwombe, Kennedyen_ZA
dc.contributor.authorLiberty, Afaafen_ZA
dc.contributor.authorMcIntyre, Jamesen_ZA
dc.contributor.authorBabiker, Abdelen_ZA
dc.contributor.authorGibb, Dianaen_ZA
dc.contributor.authorTiemessen, Caroline T.en_ZA
dc.date.accessioned2021-10-06T13:03:46Z
dc.date.available2021-10-06T13:03:46Z
dc.date.issued2019
dc.descriptionCITATION: Violari, A., et al. 2019. A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation. Nature Communications, 10:412, doi:10.1038/s41467-019-08311-0.
dc.descriptionThe original publication is available at https://www.nature.com
dc.description.abstractENGLISH ABSTRACT: Understanding HIV remission in rare individuals who initiated antiretroviral therapy (ART) soon after infection and then discontinued, may inform HIV cure interventions. Here we describe features of virus and host of a perinatally HIV-1 infected child with long-term sustained virological control. The child received early limited ART in the Children with HIV Early antiRetroviral therapy (CHER) trial. At age 9.5 years, diagnostic tests for HIV are negative and the child has characteristics similar to uninfected children that include a high CD4:CD8 ratio, low T cell activation and low CCR5 expression. Virus persistence (HIV-1 DNA and plasma RNA) is confirmed with sensitive methods, but replication-competent virus is not detected. The child has weak HIV-specific antibody and T cell responses. Furthermore, we determine his HLA and KIR genotypes. This case aids in understanding post-treatment control and may help design of future intervention strategies.en_ZA
dc.description.urihttps://www.nature.com/articles/s41467-019-08311-0
dc.description.versionPublisher's version
dc.format.extent11 pagesen_ZA
dc.identifier.citationViolari, A., et al. 2019. A child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessation. Nature Communications, 10:412, doi:10.1038/s41467-019-08311-0
dc.identifier.issn2041-1723 (online)
dc.identifier.otherdoi:10.1038/s41467-019-08311-0
dc.identifier.urihttp://hdl.handle.net/10019.1/123144
dc.language.isoen_ZAen_ZA
dc.publisherNature Research (part of Springer Nature)en_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectPerinatal HIV infectionen_ZA
dc.subjectMedical virologyen_ZA
dc.subjectHIV infection -- Obstetricsen_ZA
dc.subjectAntiretroviralsen_ZA
dc.subjectImmunophenotypingen_ZA
dc.titleA child with perinatal HIV infection and long-term sustained virological control following antiretroviral treatment cessationen_ZA
dc.typeArticleen_ZA
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