Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency
dc.contributor.author | Becker, W. B. | en_ZA |
dc.contributor.author | Engelbrecht, S. | en_ZA |
dc.contributor.author | Becker, M. L. B. | en_ZA |
dc.contributor.author | Piek, C. | en_ZA |
dc.contributor.author | Robson, B. A. | en_ZA |
dc.contributor.author | Wood, L. | en_ZA |
dc.contributor.author | Jacobs, P. | en_ZA |
dc.date.accessioned | 2011-03-18T14:59:36Z | |
dc.date.available | 2011-03-18T14:59:36Z | |
dc.date.issued | 1988-12 | |
dc.description | CITATION: Becker W. B., et al. 1988. Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency. A case report. S Afr Med J, 74:610-614. | en_ZA |
dc.description | The original publication is available at http://www.samj.org.za | en_ZA |
dc.description.abstract | A new human helper (CD4) T-lymphotropic herpesvirus (HTLHV) was first isolated in February 1985 from the cultured peripheral blood lymphocytes (PBL) of a patient with the acquired immunodeficiency syndrome, and subsequently from the PBL of 1 patient with hairy cell leukaemia and 2 patients with lymphoproliferative disease associated with human T-lymphotropic virus type I infection. The viruses could be serially subcultured in umbilical cord PBL cultures in which they infected helper (CD4) T-lymphocytes producing multinucleate giant cells with intranuclear inclusions followed by cell lysis. Electron microscopy of infected cultures revealed that the isolates were herpesviruses. Specific DNA probing showed that the 4 isolates were related to one another but were distinct from cytomegalovirus, Epstein-Barr virus, Herpes-virus hominis types 1 and 2, and varicella-zoster virus. HTLHV lyses the same target cell as human immunodeficiency virus in PBL cultures suggesting that it may have a similar potential to cause acquired immune deficiency. The development of an unequivocally diagnostic serological test is a priority, so that the epidemiology and pathogenesis of HTLHV infection can be studied. | en_ZA |
dc.description.version | Publisher’s version | en_ZA |
dc.identifier.citation | Becker W. B., et al. 1988. Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency. A case report. S Afr Med J, 74:610-614. | en_ZA |
dc.identifier.issn | 2078-5135 (online) | |
dc.identifier.issn | 0256-9574 (print) | |
dc.identifier.uri | http://hdl.handle.net/10019.1/7928 | |
dc.language.iso | en | |
dc.publisher | Health & Medical Publishing Group | en_ZA |
dc.rights.holder | South African Medical Journal | en_ZA |
dc.subject | herpesvirus | en_ZA |
dc.subject | blood lymphocyte | en_ZA |
dc.subject | immune deficiency | en_ZA |
dc.title | Isolation of a new human herpesvirus producing a lytic infection of helper (CD4) T-lymphocytes in peripheral blood lymphocyte cultures. Another cause of acquired immunodeficiency | en_ZA |
dc.type | Article | en_ZA |
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