Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women : a systematic review protocol

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dc.contributor.authorChibawara, Trusten_ZA
dc.contributor.authorMbuagbaw, Lawrenceen_ZA
dc.contributor.authorKitenge, Marcelen_ZA
dc.contributor.authorNyasulu, Peter S.en_ZA
dc.date.accessioned2021-11-16T07:14:28Z
dc.date.available2021-11-16T07:14:28Z
dc.date.issued2019-03-05
dc.descriptionCITATION: Chibawara, T. et al. 2019. Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol. Systematic Reviews, 8(68). doi:10.1186/s13643-019-0982-z
dc.descriptionThe original publication is available at https://systematicreviewsjournal.biomedcentral.com/about
dc.description.abstractBackground: The HIV/AIDS pandemic has struck regions, countries, and populations in different ways. With the introduction of antiretroviral drugs, people living with HIV (PLHIV) have a much better prognosis, even though there are still many new infections in young women. The role of widespread antiretroviral therapy (ART) on the incidence of HIV in young women is unknown. Methods: We will conduct a comprehensive search of MEDLINE (PubMed), Excerpta Medica database (EMBASE), Scopus, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), World Health Organization’s (WHO’s) library database, Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts, and gray literature sources to identify any relevant literature. We will include randomized and non-randomized clinical trials and cohort studies in which ART was offered to adults aged 18 and above reporting outcomes in females aged 15 to 24 years. The outcomes of interest are HIV incidence, ART initiation, adherence, retention, and viral load suppression. We will screen titles, abstracts, and the full texts of relevant articles in duplicate. Disagreements will be resolved by consensus. We will extract data on the risk of HIV infection in younger females after the use of ART in the adult population. Discussion: To our knowledge, this is the first systematic review to look at the impact of ART use among adults on HIV incidence in young women. The results of this review will be used in a modeling study to simulate the effects of using ART as an effective tool to prevent sexual transmission of HIV to young women. Our findings will inform the treatment-as-prevention (TasP) strategy to reduce new HIV infections among young women.en_ZA
dc.description.urihttps://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-019-0982-z
dc.description.versionPublisher’s version
dc.format.extent6 pages
dc.identifier.citationChibawara, T. et al. 2019. Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol. Systematic Reviews, 8(68). doi:10.1186/s13643-019-0982-z
dc.identifier.issn2046-4053 (online)
dc.identifier.otherdoi:10.1186/s13643-019-0982-z
dc.identifier.urihttp://hdl.handle.net/10019.1/123460
dc.language.isoen_ZAen_ZA
dc.publisherBMC
dc.rights.holderAuthors retain copyright
dc.subjectHighly active antiretroviral therapyen_ZA
dc.subjectHIV (Viruses) -- Transmission -- Age factorsen_ZA
dc.subjectHIV-positive women -- Transmission -- Incidenceen_ZA
dc.subjectHIV-positive youth -- Transmission -- Incidenceen_ZA
dc.subjectPatient complianceen_ZA
dc.subjectSystematic reviews (Medical research)en_ZA
dc.titleEffects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women : a systematic review protocolen_ZA
dc.typeArticleen_ZA
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