Effect of simplified dietary advice on nutritional status and uremic toxins in chronic kidney disease participants

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dc.contributor.authorEbrahim, Zarinaen_ZA
dc.contributor.authorGlorieux, Grieten_ZA
dc.contributor.authorMoosa, Rafique M.en_ZA
dc.contributor.authorBlaauw, Renéeen_ZA
dc.date.accessioned2024-02-12T09:40:01Z
dc.date.available2024-02-12T09:40:01Z
dc.date.issued2022-11-29en_ZA
dc.descriptionThe original publication is available at: http://www.sajcn.co.zaen_ZA
dc.description.abstractBackground: Traditional chronic kidney disease (CKD) dietary advice is challenging with many restrictions, consequently adherence to the CKD diet is low. Recent literature has proposed less restrictive dietary guidelines in CKD to improve dietary adherence and outcomes; however, limited evidence of its implementation exists. Objectives: This study (trial number: PACTR202002892187265) investigated the effect of simplified dietary advice on nutritional outcomes and adherence after four weeks of dietary advice. Design: A before-and-after study was conducted. Outcome measures: Sociodemographic, clinical and biochemical information was collected and anthropometric measurements performed on Stage 3–5 CKD participants attending a pre-dialysis clinic. Uremic toxins were quantified by UPLC/fluorescence detection. Dietary intake was assessed using a quantified food frequency questionnaire (QFFQ). Participants were educated by the study dietitian on simplified dietary advice using an infographic. A diet-adherence score sheet monitored adherence. All outcomes were measured at baseline and four weeks after the diet was advised. IBM SPSS® version 27 was used for statistical analysis. Results: Fifty-nine participants, mean age 41.0 ± 11.6 years, completed the study. After four weeks, significant improvements were found in body mass index (p < 0.006), waist circumference (p < 0.001), mid-upper arm circumference (p < 0.001), serum total cholesterol (p < 0.045), serum triglycerides (p < 0.017), energy (p < 0.001), protein (p < 0.001) and most dietary intake variables. Overweight and obesity prevalence was high at 68%. Uremic toxin concentrations remained stable. Dietary adherence was 88.6%. Conclusion: The simplified dietary advice suggests improved nutritional outcomes in CKD patients who were predominantly overweight and obese, without compromising kidney function. This study highlights the importance and feasibility of simplified nutrition education in CKD.en_ZA
dc.description.urihttp://www.sajcn.co.za/index.php/SAJCN/article/view/1636en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent9 pagesen_ZA
dc.identifier.citationEbrahim, Z., Glorieux, G., Moosa, M., & Blaauw, R. (2022). Effect of simplified dietary advice on nutritional status and uremic toxins in chronic kidney disease participants. South African Journal of Clinical Nutrition, 35(4):168–176 pages. doi.10.1080/16070658.2021.2018788en_ZA
dc.identifier.doi10.1080/16070658.2021.2018788en_ZA
dc.identifier.issn1607-0658 (print)en_ZA
dc.identifier.issn2221-1268 (online)en_ZA
dc.identifier.orcid0000-0001-8612-1839en_ZA
dc.identifier.orcid0000-0002-7641-4707en_ZA
dc.identifier.orcid0000-0003-1696-0113en_ZA
dc.identifier.orcid0000-0001-7413-5918en_ZA
dc.identifier.urihttps://scholar.sun.ac.za/handle/10019.1/129277
dc.language.isoen_ZAen_ZA
dc.publisherTaylor & Francisen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subject.lcshChronic renal failure -- Diet therapy en_ZA
dc.subject.lcshChronic renal failure -- Nutritional aspectsen_ZA
dc.subject.lcshKidneys -- Diseases -- Diet therapyen_ZA
dc.subject.lcshKidneys -- Diseases -- Nutritional aspectsen_ZA
dc.titleEffect of simplified dietary advice on nutritional status and uremic toxins in chronic kidney disease participantsen_ZA
dc.typeArticleen_ZA
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