Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected
dc.contributor.author | Abdullah, Ibtisam | en_ZA |
dc.contributor.author | Nell, Erica-Mari | en_ZA |
dc.contributor.author | Chapanduka, Zivanai C. | en_ZA |
dc.date.accessioned | 2020-09-22T06:51:56Z | |
dc.date.available | 2020-09-22T06:51:56Z | |
dc.date.issued | 2020-05-25 | |
dc.description | CITATION: Abdullah, I., Nell, E. M. & Chapanduka, Z. C. 2020. Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected. South African Journal of Oncology, 4:a121, doi:10.4102/sajo.v4i0.121. | |
dc.description | The original publication is available at https://sajo.org.za | |
dc.description.abstract | ENGLISH ABSTRACT: This case study explores a clinicopathological presentation of Adult T-cell leukaemia/lymphoma (ATLL) at Tygerberg Hospital; a disease associated with adulthood noted in an adolescent patient. Adult T-cell leukaemia–lymphoma oncogenesis develops through a multistep process with an accumulation of mutations. Infection through human T-lymphotropic virus type 1 (HTLV-1) is the first step of a multistep process resulting in eventual clonal proliferation of mature T-cells. There is a long latency period of 20–50 years from the time of infection with HTLV-1 to the development of symptoms of ATLL; thus, ATLL is a malignancy associated with adulthood. The median age of diagnosis is 58, ranging from the third to ninth decade of life. This is an ideal learning case as it highlights the importance of recognising ATLL in children and young adults in our population. | en_ZA |
dc.description.uri | https://sajo.org.za/index.php/sajo/article/view/121 | |
dc.description.version | Publisher's version | |
dc.format.extent | 4 pages | en_ZA |
dc.identifier.citation | Abdullah, I., Nell, E. M. & Chapanduka, Z. C. 2020. Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected. South African Journal of Oncology, 4:a121, doi:10.4102/sajo.v4i0.121 | |
dc.identifier.issn | 2523-0646 (online) | |
dc.identifier.issn | 2518-8704 (print) | |
dc.identifier.other | doi:10.4102/sajo.v4i0.121 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/108834 | |
dc.language.iso | en_ZA | en_ZA |
dc.publisher | AOSIS | en_ZA |
dc.rights.holder | Authors retain copyright | en_ZA |
dc.subject | Flower cells | en_ZA |
dc.subject | Human T-cell leukemia-lymphoma viruses | en_ZA |
dc.subject | Lymphoproliferative disorders | en_ZA |
dc.subject | Adolescents | en_ZA |
dc.title | Adult T-cell leukaemia / lymphoma in an adolescent patient : expect the unexpected | en_ZA |
dc.type | Article | en_ZA |