Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease

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dc.contributor.authorPretorius, Etheresiaen_ZA
dc.contributor.authorPage, Martin J.en_ZA
dc.contributor.authorMbotwe, Sthembileen_ZA
dc.contributor.authorKell, Douglas B.en_ZA
dc.date.accessioned2018-03-12T07:32:15Z
dc.date.available2018-03-12T07:32:15Z
dc.date.issued2018
dc.descriptionCITATION: Pretorius, E., et al. 2018. Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS ONE, 13(3):e0192121, doi:10.1371/journal.pone.0192121.en_ZA
dc.descriptionThe original publication is available at http://journals.plos.org/plosoneen_ZA
dc.descriptionPublication of this article was funded by the Stellenbosch University Open Access Fund.en_ZA
dc.description.abstractThe thrombin-induced polymerisation of fibrinogen to form fibrin is well established as a late stage of blood clotting. It is known that Parkinson’s Disease (PD) is accompanied by dysregulation in blood clotting, but it is less widely known as a coagulopathy. In recent work, we showed that the presence of tiny amounts of bacterial lipopolysaccharide (LPS) in healthy individuals could cause clots to adopt an amyloid form, and this could be observed via scanning electron microscopy (SEM) or via the fluorescence of thioflavin-T. This could be prevented by the prior addition of lipopolysaccharide-binding protein (LBP). We had also observed by SEM this unusual clotting in the blood of patients with Parkinson’s Disease. We hypothesised, and here show, that this too can be prevented by LBP in the context of PD. This adds further evidence implicating inflammatory microbial cell wall products as an accompaniment to the disease, and may be part of its aetiology. This may lead to novel treatment strategies in PD designed to target microbes and their products.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0192121
dc.description.versionPublisher's versionen_ZA
dc.format.extent16 pages : illustrationsen_ZA
dc.identifier.citationPretorius, E., et al. 2018. Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease. PLoS ONE, 13(3):e0192121, doi:10.1371/journal.pone.0192121en_ZA
dc.identifier.issn1932-6203 (online)
dc.identifier.otherdoi:10.1371/journal.pone.0192121
dc.identifier.urihttp://hdl.handle.net/10019.1/103220
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectParkinson’s diseaseen_ZA
dc.subjectLipopolysaccharide-binding protein (LBP)en_ZA
dc.subjectScanning electron microscopy (SEM)en_ZA
dc.subjectParkinson's disease -- Treatmenten_ZA
dc.titleLipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's diseaseen_ZA
dc.typeArticleen_ZA
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