Parkinson’s disease : a systemic inflammatory disease accompanied by bacterial inflammagens

Simple item page
dc.contributor.authorAdams, Buinen_ZA
dc.contributor.authorNunes, J. Massimoen_ZA
dc.contributor.authorPage, Martin J.en_ZA
dc.contributor.authorRoberts, Timothyen_ZA
dc.contributor.authorCarr, Jonathanen_ZA
dc.contributor.authorNell, Theo A.en_ZA
dc.contributor.authorKell, Douglas B.en_ZA
dc.contributor.authorPretorius, Etheresiaen_ZA
dc.date.accessioned2021-11-04T09:56:14Z
dc.date.available2021-11-04T09:56:14Z
dc.date.issued2019-08-27
dc.descriptionCITATION: Adams, B., et al. 2019. Parkinson’s disease : a systemic inflammatory disease accompanied by bacterial inflammagens. Frontiers in Aging Neuroscience, 11:210, doi:10.3389/fnagi.2019.00210.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractParkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of its presence in a PD population. To further elucidate the action of this gingipain, as well as the action of the lipopolysaccharide (LPS) from P. gingivalis, low concentrations of recombinant RgpA and LPS were added to purified fluorescent fibrinogen. We also substantiate previous findings regarding PD by emphasizing the presence of systemic inflammation via multiplex cytokine analysis, and demonstrate hypercoagulation using thromboelastography (TEG), confocal and electron microscopy. Biomarker analysis confirmed significantly increased levels of circulating proinflammatory cytokines. In our PD and control blood analysis, our results show increased hypercoagulation, the presence of amyloid formation in plasma, and profound ultrastructural changes to platelets. Our laboratory analysis of purified fibrinogen with added RgpA, and/or LPS, showed preliminary data with regards to the actions of the protease and the bacterial membrane inflammagen on plasma proteins, to better understand the nature of established PD.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnagi.2019.00210/full
dc.description.versionPublisher's version
dc.format.extent17 pages : illustrationsen_ZA
dc.identifier.citationAdams, B., et al. 2019. Parkinson’s disease : a systemic inflammatory disease accompanied by bacterial inflammagens. Frontiers in Aging Neuroscience, 11:210, doi:10.3389/fnagi.2019.00210
dc.identifier.issn1663-4365 (online)
dc.identifier.otherdoi:10.3389/fnagi.2019.00210
dc.identifier.urihttp://hdl.handle.net/10019.1/123359
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Media
dc.rights.holderAuthors retain copyright
dc.subjectParkinson’s diseaseen_ZA
dc.subjectSystemic inflammationen_ZA
dc.subjectPorphyromonas gingivalisen_ZA
dc.subjectCytokinesen_ZA
dc.subjectLipopolysaccharide (LPS)en_ZA
dc.titleParkinson’s disease : a systemic inflammatory disease accompanied by bacterial inflammagensen_ZA
dc.typeArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
adams_parkinson_2019.pdf
Size:
4.33 MB
Format:
Adobe Portable Document Format
Description:
Download article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Research Articles (Physiological Sciences)
Research Articles (Neurology)